M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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DNA-binding activity of Jun is increased through its interaction with Fos.
TL;DR: It is shown that the DNA‐binding activity of bacterially expressed trpE‐Jun fusion proteins is increased many‐fold upon their interaction with Fos (or a Fos‐relaied antigen) expressed from a baculovirus vector.
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NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation
Difeng Fang,Kun He,Na Wang,Zhihong Sang,Xin Qiu,Guang Xu,Zhao Jian,Bing Liang,Tao Li,Hui-Yan Li,Ai-Ling Li,Tao Zhou,Wei-Li Gong,Baoli Yang,Michael Karin,Xue-Min Zhang,Wei-Hua Li +16 more
TL;DR: It is reported that the neural precursor cell expressed developmentally downregulated protein 4 (NEDD4), homologous to E6-AP Carboxyl Terminus family E3 ubiquitin ligase, is a novel component of the CD40 signalling complex.
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Anthrax lethal factor and edema factor act on conserved targets in Drosophila.
TL;DR: It is demonstrated that anthrax toxins function in Drosophila as they do in mammalian cells and open the way to using Drosophile as a multicellular host system for studying the in vivo function of diverse toxins and virulence factors.
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Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.
Mei-Fei Yueh,Feng He,Chen Chen,Catherine Vu,Anupriya Tripathi,Rob Knight,Michael Karin,Shujuan Chen,Robert H. Tukey +8 more
TL;DR: It is demonstrated that, along with HFD, TCS induces hepatic steatosis and steatohepatitis jointly regulated by the transcription factor ATF4 and the nuclear receptor PPARα, which participate in the transcriptional regulation of the Fgf21 gene.
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Is NF-κB2/p100 a direct activator of programmed cell death?
Hans Häcker,Michael Karin +1 more
TL;DR: It is suggested that loss of the proapoptotic function of NF-κB2/p100 is directly linked to its oncogenic activity in lymphomas.