M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
NF-kB as a Critical Link Between Inflammation and Cancer
TL;DR: Through its ability to up-regulate the expression of tumor promoting cytokines, such as IL-6 or TNF-a, and survival genes,such as Bcl-XL, NF-kB provides a critical link between inflammation and cancer.
Journal ArticleDOI
Loss of Ikkβ Promotes Migration and Proliferation of Mouse Embryo Fibroblast Cells
TL;DR: The data presented indicate that generation of ROS played a key role in the morphological and mobility changes in Ikkβ-/- cells, and suggest that IKKβ provides inhibitory signals for cell mobility and growth.
Journal Article
Conditional Deletion of IkappaB-Kinase-beta Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia
Wataru Shibata,Shigeo Takaishi,Sureshkumar Muthupalani,D. Mark Pritchard,Mark T. Whary,Arlin B. Rogers,James G. Fox,Kelly S. Betz,Klaus H. Kaestner,Michael Karin,Timothy C. Wang +10 more
TL;DR: The loss of IKKbeta/NF-kappaB signaling in GECs results in increased apoptosis and necrosis in response to cellular stress, and accelerated development of dysplasia by Helicobacter infection.
Journal ArticleDOI
Cell-Selective Inhibition of NF-κB Signaling Improves Therapeutic Index in a Melanoma Chemotherapy Model
Thomas Enzler,Yasuyo Sano,Min-Kyung Choo,Howard B. Cottam,Michael Karin,Hensin Tsao,Jin Mo Park +6 more
TL;DR: The findings show that the IκB kinase–NF-κB signaling pathway is important for both promoting treatment resistance and preventing host toxicity in cancer chemotherapy; however, the two functions are exerted by distinct cell type–specific mechanisms and can therefore be selectively targeted to achieve an improved therapeutic outcome.
Journal ArticleDOI
Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.
Megan M. Kaneda,Karen Messer,Natacha Ralainirina,Hongying Li,Christopher J. Leem,Sara Gorjestani,Gyunghwi Woo,Abraham V. Nguyen,Camila C. Figueiredo,Philippe Foubert,Michael C. Schmid,Melissa Pink,David G. Winkler,Matthew Rausch,Vito J. Palombella,Jeffery L. Kutok,Karen McGovern,Kelly A. Frazer,Xuefeng Wu,Michael Karin,Roman Sasik,Ezra E.W. Cohen,Judith A. Varner +22 more
TL;DR: This corrects the article to say that the author of the paper was a post-graduate student at the University of Wisconsin-Madison, rather than a professor, as previously reported.