M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Sphingolipids: The Oil on the TRAFire That Promotes Inflammation
Gennaro Napolitano,Michael Karin +1 more
TL;DR: New evidence shows that sphingosine-1-phosphate (S1P), a sphingolipid that is synthesized during inflammatory responses, is an essential cofactor for TRAF2 ubiquitin ligase activity and introduces lipid second messengers into the realm of TNFR and TLR signaling.
Journal ArticleDOI
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Sukumar Namineni,Sukumar Namineni,Tracy O'Connor,Tracy O'Connor,Suzanne Faure-Dupuy,Pål Johansen,Tobias Riedl,Kaijing Liu,Haifeng Xu,Indrabahadur Singh,Prashant V. Shinde,Fanghui Li,Aleksandra A. Pandyra,Piyush Sharma,Piyush Sharma,Marc Ringelhan,Marc Ringelhan,Andreas Muschaweckh,Katharina Borst,Patrick Blank,Sandra Lampl,Katharina Neuhaus,David Durantel,Rayan Farhat,Achim Weber,Daniela Lenggenhager,Thomas M. Kündig,Peter Staeheli,Ulrike Protzer,Ulrike Protzer,Dirk Wohlleber,Bernhard Holzmann,Marco Binder,Kai Breuhahn,Lisa Mareike Assmus,Jacob Nattermann,Zeinab Abdullah,Maude Rolland,Emmanuel Dejardin,Philipp A. Lang,Karl S. Lang,Michael Karin,Julie Lucifora,Ulrich Kalinke,Percy A. Knolle,Mathias Heikenwalder,Mathias Heikenwalder +46 more
TL;DR: Data show that hepatocyte-intrinsic NF-κB is a vital amplifier of interferon-α/β signaling pivotal for early, strong ISG responses, influx of immune cells and hepatic viral clearance.
Journal ArticleDOI
Immunoregulatory genes and immunosuppression by glucocorticoids
TL;DR: In spite of the widespread use of glucocorticoids, the molecular mechanisms that underlie their therapeutic effects are poorly understood as mentioned in this paper, and they are widely used as immunosuppressive and antiinflammatory agents.
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Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis
Stefanie Marek-Iannucci,Asli Beyza Ozdemir,Debbie Moreira,Angela C. Gomez,Malcolm Lane,Rebecca A. Porritt,Youngho Lee,Kenichi Shimada,Masanori Abe,Aleksandr Stotland,David Zemmour,Sarah J. Parker,Elsa Sanchez-Lopez,Jennifer E. Van Eyk,Roberta A. Gottlieb,Michael C. Fishbein,Michael Karin,Timothy R. Crother,Magali Noval Rivas,Moshe Arditi +19 more
TL;DR: In this paper, the role of autophagy/mitophagy on cardiovascular lesion development was examined using the Lactobacillus casei cell wall extract (LCWE) model of KD vasculitis.
Journal ArticleDOI
NF-κB: A Double-Edged Sword Controlling Inflammation
TL;DR: The current understanding about the pro- and anti-inflammatory roles of NF-κB is reviewed and the implication of its dichotomous inflammation-modulating activity in the context of inflammasome activation and tumorigenesis is discussed.