M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
Zuoning Han,David L. Boyle,Lufen Chang,Brydon L. Bennett,Michael Karin,Li Yang,Anthony M. Manning,Gary S. Firestein +7 more
TL;DR: The novel JNK inhibitor SP600125 completely blocked IL-1--induced accumulation of phospho-Jun and induction of c-Jun transcription in synoviocytes and in joint arthritis, indicating that JNK is an important therapeutic target for RA.
Journal ArticleDOI
IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy
TL;DR: Inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation- induced tumor growth to inflammation-induced tumor regression.
Journal ArticleDOI
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
Zhenyu Zhong,Atsushi Umemura,Atsushi Umemura,Elsa Sanchez-Lopez,Shuang Liang,Shabnam Shalapour,Jerry Wong,Feng He,Daniela Boassa,Guy Perkins,Syed Raza Ali,Matthew D. McGeough,Mark H. Ellisman,Ekihiro Seki,Ekihiro Seki,Åsa B. Gustafsson,Hal M. Hoffman,Maria T. Diaz-Meco,Jorge Moscat,Michael Karin +19 more
TL;DR: The "NF-κB-p62-mitophagy" pathway is a macrophage-intrinsic regulatory loop through which NF-κBs restrains its own inflammation-promoting activity and orchestrates a self-limiting host response that maintains homeostasis and favors tissue repair.
Journal ArticleDOI
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus
Michael Karin,Tony Hunter +1 more
TL;DR: This work has shown that transcription factors are kept in a latent state in the cytoplasm and are translocated into the nucleus upon activation, where they phosphorylate target transcription factors.
Journal ArticleDOI
The regulation of AP-1 activity by mitogen-activated protein kinases.
TL;DR: The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.