M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B.
TL;DR: Using a variety of protease inhibitors, some of which have specificity towards the multicatalytic proteinase complex, it is demonstrated that degradation of I kappa B alpha is required for NF-kappa B activation.
Journal ArticleDOI
IKKα controls formation of the epidermis independently of NF-κB
Yinling Hu,Véronique Baud,Takefumi Oga,Takefumi Oga,Keun Il Kim,Kazuhiko Yoshida,Kazuhiko Yoshida,Michael Karin +7 more
TL;DR: It is shown that the unique function of IKKα in control of keratinocyte differentiation is not exerted through its IκB kinase activity or through NF-κB, but instead, IKK α controls production of a soluble factor that induces keratinocytes differentiation.
Journal ArticleDOI
Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase
Pankaj Kapahi,Takayuki Takahashi,Gioacchino Natoli,Stephen R. Adams,Yi Chen,Roger Y. Tsien,Michael Karin +6 more
TL;DR: Overexpression of IKKβ (C179A) protects NF-κB from inhibition by arsenite, indicating that despite the involvement of a large number of distinct gene products in this activation pathway, the critical target for inhibition by arsenic is on the IKK catalytic subunits.
Journal ArticleDOI
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death.
Nancy Lassignal Johnson,Anne M. Gardner,Katrina M. Diener,Carol A. Lange-Carter,Janice Gleavy,Janice Gleavy,Matthew B. Jarpe,Audrey Minden,Michael Karin,Leonard I. Zon,Gary L. Johnson,Gary L. Johnson +11 more
TL;DR: Expression of activated MEKK enhanced the apoptotic response to ultraviolet irradiation, indicating that MEKK-regulated pathways sensitize cells to apoptotic stimuli.
Journal ArticleDOI
Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?
TL;DR: The importance of autocrine interleukin 6 (IL-6) in lung and breast cancers and implicate IL-6 as an important activator of oncogenic STAT3 in lung adenocarcinomas and of Jagged-1/Notch signaling in breast tumor mammospheres are outlined.