M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
The anti-death machinery in IKK/NF-kappaB signaling.
TL;DR: Intervention of IKK/NF-κB signaling would be a promising option to improve the efficacy of cancer treatment and help tumor cells to escape the killing of conventional anti-cancer therapies.
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Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Xuefeng Wu,Weizhou Zhang,Joan Font-Burgada,Trenis Palmer,Alexander S. Hamil,Subhra K. Biswas,Michael Poidinger,Nicholas Borcherding,Qing Xie,Lesley G. Ellies,Nikki K. Lytle,Li Wha Wu,Raymond G. Fox,Jing Yang,Steven F. Dowdy,Tannishtha Reya,Michael Karin +16 more
TL;DR: It is demonstrated that ubiquitin-conjugating enzyme Ubc13, whose expression is elevated in primary and metastatic breast cancer (BCa), promotes metastatic spread of BCa cells by controlling their lung-colonizing ability while having little effect on primary tumor growth.
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IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression.
Mo Liu,Dung Fang Lee,Dung Fang Lee,Chun Te Chen,Chun Te Chen,Chia Jui Yen,Long Yuan Li,Hong Jen Lee,Hong Jen Lee,Chun Ju Chang,Wei Chao Chang,Wei Chao Chang,Jung Mao Hsu,Jung Mao Hsu,Hsu Ping Kuo,Hsu Ping Kuo,Weiya Xia,Yongkun Wei,Pei Chun Chiu,Chao Kai Chou,Chao Kai Chou,Yi Du,Yi Du,Debanjan Dhar,Michael Karin,Chung-Hsuan Chen,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung +28 more
TL;DR: A TNFα/IKKα/FOXA2/NUMB/ NUMB/NOTCH1 pathway that is critical for inflammation-mediated tumorigenesis and may provide a target for clinical intervention in human cancer is reported.
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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Hsiao-Yen Ma,Gen Yamamoto,Jun Xu,Xiao Liu,Daniel Karin,Ju Youn Kim,Ludmil B. Alexandrov,Yukinori Koyama,Takahiro Nishio,Christopher Benner,Sven Heinz,Sara Brin Rosenthal,Shuang Liang,Mengxi Sun,Gabriel Karin,Peng Zhao,Pnina Brodt,Iain H. McKillop,Oswald Quehenberger,Edward A. Dennis,Alan R. Saltiel,Hidekazu Tsukamoto,Bin Gao,Michael Karin,David A. Brenner,Tatiana Kisseleva +25 more
TL;DR: Overall, IL-17A is as a tumor promoting cytokine, which critically regulates alcohol-induced hepatic steatosis, inflammation, fibrosis, and HCC.
Journal ArticleDOI
Supreme EnLIGHTenment: Damage Recognition and Signaling in the Mammalian UV Response
TL;DR: This review focuses on how photonic energy and its primary cellular products are sensed and converted into the "language of cells"--signal reception and transduction.