M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1
Weizhou Zhang,Wei Tan,Xuefeng Wu,Maxim Poustovoitov,Amy Strasner,Wei Li,Nicholas Borcherding,Majid Ghassemian,Michael Karin +8 more
TL;DR: It is shown that IKKα and its activator, NF-κB-inducing kinase (NIK), support the expansion of tumor-initiating cells (TICs) that copurify with a CD24(med)CD49f(hi) population from premalignant ErbB2-expressing mammary glands.
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BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages
Alessandra Rosati,Anna Basile,Raffaella D'Auria,Morena d'Avenia,Margot De Marco,Antonia Falco,Michelina Festa,Luana Guerriero,Vittoria Iorio,Roberto Parente,Maria Pascale,Liberato Marzullo,Renato Franco,Claudio Arra,Antonio Barbieri,Domenica Rea,Giulio Menichini,Michael Hahne,Maarten F. Bijlsma,Daniela Barcaroli,Gianluca Sala,Fabio F. di Mola,Pierluigi Di Sebastiano,Jelena Todoric,Laura Antonucci,Vincent Corvest,Anass Jawhari,Matthew A. Firpo,David A. Tuveson,Mario Capunzo,Michael Karin,Vincenzo De Laurenzi,Maria Caterina Turco +32 more
TL;DR: It is reported that PDAC cells secrete BAG3, which binds and activates macrophages, inducing their activation and the secretion of PDAC supporting factors, and it is shown that an anti-BAG3 antibody has therapeutic potential.
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Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage
Syed Raza Ali,Anjuli M. Timmer,Anjuli M. Timmer,Sameera Bilgrami,Eek Joong Park,Lars Eckmann,Victor Nizet,Victor Nizet,Michael Karin +8 more
TL;DR: Using virulent and nonvirulent strains of Bacillus anthracis, it is shown that secretion of ATP by infected macrophages and the sequential activation of the P2X7 purinergic receptor and nucleotide binding oligomerization domain (NOD)-like receptors are critical for IL-1-dependent host protection from virulent B. anthracis.
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Sestrin regulation of TORC1: Is Sestrin a leucine sensor?
TL;DR: New findings suggest that the amino acid leucine specifically disrupts the association of Sestrin2 with GATOR2, thus explaining howLeucine and related amino acids stimulate TORC1 activity.
Journal ArticleDOI
Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma.
Mark Yarchoan,Parul Agarwal,Augusto Villanueva,Shuyun Rao,Laura A. Dawson,Josep M. Llovet,Josep M. Llovet,Richard S. Finn,John D. Groopman,Hashem B. El-Serag,Satdarshan P.S. Monga,Xin Wei Wang,Michael Karin,Robert E. Schwartz,Kenneth K. Tanabe,Lewis R. Roberts,Preethi H. Gunaratne,Allan Tsung,Kimberly A Brown,Theodore S. Lawrence,Riad Salem,Amit G. Singal,Amy K. Kim,Atoosa Rabiee,Linda M.S. Resar,Yujin Hoshida,Aiwu Ruth He,Kalpana Ghoshal,Patrick B. Ryan,Elizabeth M. Jaffee,Chandan Guha,Lopa Mishra,Lopa Mishra,C. Norman Coleman,Mansoor M. Ahmed +34 more
TL;DR: New treatment opportunities, controversies, and future directions in managing HCC are discussed, including genomics, underlying cirrhosis, and optimal use of treatment strategies that include radiation, liver transplantation, and surgery.