M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death
Ik-Hyun Cho,Jin Pyo Hong,Eun Cheng Suh,Jaehwan Kim,Hyunkyoung Lee,Jong Eun Lee,Soojin Lee,Chong-Hyun Kim,Dong Woon Kim,Eun-Kyeong Jo,Kyung Eun Lee,Michael Karin,Sung Joong Lee +12 more
TL;DR: It is concluded that IKK/nuclear factor-kappaB dependent microglia activation contributes to KA-induced hippocampal neuronal cell death in vivo through induction of inflammatory mediators.
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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
Hua Su,Fei Yang,Rao Fu,Xin Li,Randall French,Evangeline Mose,Xiaohong Pu,Brittney Trinh,Avi Kumar,Junlai Liu,Laura Antonucci,Jelena Todoric,Yuan Liu,Yinling Hu,Maria T. Diaz-Meco,Jorge Moscat,Christian M. Metallo,Andrew M. Lowy,Beicheng Sun,Michael Karin +19 more
TL;DR: In this article, an autophagy-inhibiting monotherapies have not demonstrated potent anti-cancer activity, but they have been shown to upregulate and utilize an alternative nutrient procurement pathway: macropinocytosis (MP) that allows tumor cells to extract nutrients from extracellular sources and use them for energy generation.
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Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases
Seong-Jin Kim,Robert Lafyatis,Kyung Young Kim,Peter Angel,Hirota Fujiki,Michael Karin,Michael B. Sporn,Anita B. Roberts +7 more
TL;DR: It is suggested that phosphorylation regulates collagenase gene expression mediated by an AP-1 binding site through a region known to contain multiple regulatory elements.
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IκB Kinase Complex α Kinase Activity Controls Chemokine and High Endothelial Venule Gene Expression in Lymph Nodes and Nasal-Associated Lymphoid Tissue
TL;DR: A critical role for IKKα is revealed in LN and NALT development, analysis of LTβ−/− mice identifies GlyCAM-1 and high endothelial cell sulfotransferase as new IKK α-dependent target genes are identified, and it is suggested that LTβR signaling on HEV can regulate HEV-specific gene expression.
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Primary induction of metallothionein by dexamethasone in cultured rat hepatocytes
TL;DR: The glucocorticoid induction of metallothionein in primary cultures of rat hepatocytes is not mediated through elevation of Zn++ uptake, and the dexamethasone stimulated increase in Zn ++ uptake is inhibited by cycloheximide.