M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression
TL;DR: It is shown that mice lacking c-Jun N-terminal kinase 1 (JNK1) exhibit reduced pathological angiogenesis and lower levels of retinal VEGF production in a murine model of ROP, and that JNK1 represents a new pharmacological target for treatment of diseases where excessive neoangiogenesis is the underlying pathology.
Journal ArticleDOI
Sestrins at the crossroad between stress and aging.
TL;DR: It is suggested that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.
Journal ArticleDOI
Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases
TL;DR: Findings suggest that such cytokines or the cells that produce them may provide new therapeutic or preventive targets in forms of colorectal cancer that are linked to inflammation.
Journal ArticleDOI
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.
Feng He,Laura Antonucci,Shinichiro Yamachika,Zechuan Zhang,Koji Taniguchi,Atsushi Umemura,Georgia Hatzivassiliou,Merone Roose-Girma,Miguel Reina-Campos,Angeles Duran,Maria T. Diaz-Meco,Jorge Moscat,Beicheng Sun,Michael Karin +13 more
TL;DR: NRF2, a transcription factor readily activated by xenobiotics, oxidative stress and autophagy disruptors, may be a common mediator of hepatomegaly; its effects on hepatic metabolism can be reversed by AKT and tyrosine kinase inhibitors.
Journal ArticleDOI
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
Monica Guma,Jun-ichi Kashiwakura,Brian Crain,Yuko Kawakami,Bruce Beutler,Gary S. Firestein,Toshiaki Kawakami,Michael Karin,Maripat Corr +8 more
TL;DR: It is shown that c-Jun N-terminal kinase (JNK) 1, but not JNK2, is critical for joint swelling and destruction in a serum transfer model of arthritis.