M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2
Michael Karin,Debanjan Dhar +1 more
TL;DR: Surprisingly, NRF2, a transcription factor that was initially thought to protect the liver from oxidative stress, was found to play a key role in promoting HCC pathogenesis.
Journal ArticleDOI
Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids
TL;DR: This system should provide an excellent model for the comparative biochemistry of regulation of gene expression and deinduction kinetics for MT synthesis following removal of the two inducers (zinc and dex).
Journal ArticleDOI
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Dorit Trudler,Kristopher L. Nazor,Yvonne S. Eisele,Titas Grabauskas,Nima Dolatabadi,James C. Parker,Abdullah Sultan,Zhenyu Zhong,Marshall S. Goodwin,Yona Levites,Todd E. Golde,Jeffery W. Kelly,Michael R. Sierks,Nicholas J. Schork,Michael Karin,Rajesh Ambasudhan,Stuart A. Lipton +16 more
TL;DR: In this article, α-synuclein (αSyn) was shown to activate the NLRP3 inflammasome in human induced pluripotent stem cell (hiPSC)-derived microglia (hiMG) via dual stimulation involving Toll-like receptor 2 (TLR2) engagement and mitochondrial damage.
Journal ArticleDOI
An IKKα–E2F1–BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence
Massimo Ammirante,Ali I. Kuraishy,Shabnam Shalapour,Amy Strasner,Claudia Ramirez-Sanchez,Weizhou Zhang,Ahmed Shabaik,Michael Karin +7 more
TL;DR: It is demonstrated that infiltrating B lymphocytes and IKKα are also required for androgen-dependent expansion of epithelial progenitors responsible for prostate regeneration.
Patent
Oncoprotein protein kinase
TL;DR: An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided in this article.