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Michael Lachmann
Researcher at Santa Fe Institute
Publications - 107
Citations - 14725
Michael Lachmann is an academic researcher from Santa Fe Institute. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 40, co-authored 96 publications receiving 13021 citations. Previous affiliations of Michael Lachmann include Tel Aviv University & Hong Kong Science and Technology Parks Corporation.
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Journal ArticleDOI
A Draft Sequence of the Neandertal Genome
Richard E. Green,Johannes Krause,Adrian W. Briggs,Tomislav Maricic,Udo Stenzel,Martin Kircher,Nick Patterson,Heng Li,Weiwei Zhai,Markus Hsi-Yang Fritz,Nancy F. Hansen,Eric Durand,Anna-Sapfo Malaspinas,Jeffrey D. Jensen,Tomas Marques-Bonet,Tomas Marques-Bonet,Can Alkan,Kay Prüfer,Matthias Meyer,Hernán A. Burbano,Jeffrey M. Good,Jeffrey M. Good,Rigo Schultz,Ayinuer Aximu-Petri,Anne Butthof,Barbara Höber,Barbara Höffner,Madien Siegemund,Antje Weihmann,Chad Nusbaum,Eric S. Lander,Carsten Russ,Nathaniel Novod,Jason P. Affourtit,Michael Egholm,Christine Verna,Pavao Rudan,Dejana Brajković,Željko Kućan,Ivan Gušić,Vladimir B. Doronichev,Liubov V. Golovanova,Carles Lalueza-Fox,Marco de la Rasilla,Javier Fortea,Antonio Rosas,Ralf Schmitz,Philip L. F. Johnson,Evan E. Eichler,Daniel Falush,Ewan Birney,James C. Mullikin,Montgomery Slatkin,Rasmus Nielsen,Janet Kelso,Michael Lachmann,David Reich,David Reich,Svante Pääbo +58 more
TL;DR: The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Journal ArticleDOI
The complete genome sequence of a Neanderthal from the Altai Mountains
Kay Prüfer,Fernando Racimo,Nick Patterson,Flora Jay,Sriram Sankararaman,Susanna Sawyer,Anja Heinze,Gabriel Renaud,Peter H. Sudmant,Cesare de Filippo,Heng Li,Swapan Mallick,Michael Dannemann,Qiaomei Fu,Martin Kircher,Martin Kuhlwilm,Michael Lachmann,Matthias Meyer,Matthias Ongyerth,Michael Siebauer,Christoph Theunert,Arti Tandon,Priya Moorjani,Joseph K. Pickrell,James C. Mullikin,Samuel H. Vohr,Richard E. Green,Ines Hellmann,Philip L. F. Johnson,Hélène Blanché,Howard M. Cann,Jacob O. Kitzman,Jay Shendure,Evan E. Eichler,Ed S. Lein,Trygve E. Bakken,Liubov V. Golovanova,Vladimir B. Doronichev,Michael V. Shunkov,A.P. Derevianko,Bence Viola,Montgomery Slatkin,David Reich,Janet Kelso,Svante Pääbo +44 more
TL;DR: It is shown that interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene and a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans is established.
Journal ArticleDOI
Genome sequence of a 45,000-year-old modern human from western Siberia
Qiaomei Fu,Heng Li,Priya Moorjani,Flora Jay,Sergey Mikhailovich Slepchenko,Aleksei A. Bondarev,Philip L. F. Johnson,Ayinuer Aximu-Petri,Kay Prüfer,Cesare de Filippo,Matthias Meyer,Nicolas Zwyns,Domingo C. Salazar-García,Yaroslav V. Kuzmin,Susan G. Keates,Pavel A. Kosintsev,Dmitry Razhev,Michael P. Richards,Nikolai V. Peristov,Michael Lachmann,Katerina Douka,Thomas Higham,Montgomery Slatkin,Jean-Jacques Hublin,David Reich,Janet Kelso,T. Bence Viola,Svante Pääbo +27 more
TL;DR: The high-quality genome sequence of a ∼45,000-year-old modern human male from Siberia derives from a population that lived before—or simultaneously with—the separation of the populations in western and eastern Eurasia and carries a similar amount of Neanderthal ancestry as present-day Eurasians.
Journal ArticleDOI
Great ape genetic diversity and population history
Javier Prado-Martinez,Peter H. Sudmant,Jeffrey M. Kidd,Jeffrey M. Kidd,Heng Li,Joanna L. Kelley,Belen Lorente-Galdos,Krishna R. Veeramah,August E. Woerner,Timothy D. O’Connor,Gabriel Santpere,Alex Cagan,Christoph Theunert,Ferran Casals,Hafid Laayouni,Kasper Munch,Asger Hobolth,Anders E. Halager,Maika Malig,Jessica Hernandez-Rodriguez,Irene Hernando-Herraez,Kay Prüfer,Marc Pybus,Laurel Johnstone,Michael Lachmann,Can Alkan,Dorina Twigg,Natalia Petit,Carl Baker,Fereydoun Hormozdiari,Marcos Fernandez-Callejo,Marc Dabad,Michael L. Wilson,Laurie S. Stevison,Cristina Camprubí,Tiago Carvalho,Aurora Ruiz-Herrera,Laura Vives,Marta Melé,Teresa Abello,Ivanela Kondova,Ronald E. Bontrop,Anne E. Pusey,Felix Lankester,John Kiyang,Richard A. Bergl,Elizabeth V. Lonsdorf,Simon Myers,Mario Ventura,Pascal Gagneux,David Comas,Hans R. Siegismund,Julie Blanc,Lidia Agueda-Calpena,Marta Gut,Lucinda Fulton,Sarah A. Tishkoff,James C. Mullikin,Richard K. Wilson,Ivo Gut,Mary Katherine Gonder,Oliver A. Ryder,Beatrice H. Hahn,Arcadi Navarro,Arcadi Navarro,Joshua M. Akey,Jaume Bertranpetit,David Reich,Thomas Mailund,Mikkel H. Schierup,Christina Hvilsom,Christina Hvilsom,Aida M. Andrés,Jeffrey D. Wall,Carlos Bustamante,Michael F. Hammer,Evan E. Eichler,Evan E. Eichler,Tomas Marques-Bonet,Tomas Marques-Bonet +79 more
TL;DR: This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.
Journal ArticleDOI
Patterns of damage in genomic DNA sequences from a Neandertal
Adrian W. Briggs,Udo Stenzel,Philip L. F. Johnson,Richard E. Green,Janet Kelso,Kay Prüfer,Matthias Meyer,Johannes Krause,Michael T. Ronan,Michael Lachmann,Svante Pääbo +10 more
TL;DR: DNA sequences determined from a Neandertal, a mammoth, and a cave bear show that purines are overrepresented at positions adjacent to the breaks in the ancient DNA, suggesting that depurination has contributed to its degradation.