Michael M. Shen

TL;DR: An overview of major themes in prostate cancer research is presented, focusing on current knowledge of principal events in cancer initiation and progression, including new insights into the mechanisms of castration resistance, identification of stem cells and tumor-initiating cells, and development of mouse models for preclinical evaluation of novel therapuetics.

TL;DR: It is demonstrated that FGFR-1 is required for proper embryonic cell proliferation and for the correct axial organization of early postimplantation embryos but not for mesoderm formation.

TL;DR: This review addresses recent progress toward the central objectives of understanding parameters of normal versus abnormal prostatic development and of elucidating a molecular pathway for prostate cancer progression and focuses on key regulatory molecules that have been implicated by analysis of patterns of allelic loss in human prostate cancers and/or by reverse genetic approaches in the mouse.

TL;DR: The male sexual regulatory gene mab-3 from the nematode Caenorhabditis elegans is isolated and found that it is related to the Drosophila melanogasterSexual regulatory gene doublesex (dsx), which encodes proteins with a DNA-binding motif that is named the ‘DM domain’.

TL;DR: Genetic lineage-marking demonstrates that rare luminal cells that express Nkx3-1 in the absence of testicular androgens are bipotential and can self-renew in vivo, and single-cell transplantation assays show that CARNs can reconstitute prostate ducts in renal grafts.