Michael Mildner

TL;DR: A novel wound model based on application of negative pressure and its effects for epidermal regeneration and immune cell behaviour is presented, which recapitulates the main features of epithelial wound regeneration, and can be applied for testing wound healing therapies and investigating underlying mechanisms.

TL;DR: Decrease in these miRNAs correlated with increased transcript levels of some established target genes, especially the cdk inhibitor p21/CDKN1A, establish mi RNAs as novel markers of cell aging in humans.

TL;DR: It is demonstrated that knockdown of filaggrin expression in an organotypic skin model reproduces epidermal alterations caused by filag Grin mutations in vivo, and a link between filag grin and endogenous UVB protection is established.

TL;DR: The findings that KS tumor cells express two lymphatic EC markers in situ strongly suggest that they are related to or even derived from the lymphaticEC lineage, and lack of these antigens on cultured cells derived from KS lesions indicates that they might not represent tumor cells that grow in tissue culture, but rather other cell types present in KS lesions.

TL;DR: It is reported here that the presence of FLG mutations in Caucasians predicts dose-dependent alterations in epidermal permeability barrier function, and this results clarify how flaggrin mutations impair epidersmal permeable barrier function.