M
Michael Moore
Researcher at Cork University Hospital
Publications - 172
Citations - 12998
Michael Moore is an academic researcher from Cork University Hospital. The author has contributed to research in topics: Exchange rate & Medicine. The author has an hindex of 38, co-authored 152 publications receiving 11089 citations. Previous affiliations of Michael Moore include Queen's University Belfast & National Bureau of Economic Research.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
Wenhui Li,Chengsheng Zhang,Chengsheng Zhang,Jianhua Sui,Jens H. Kuhn,Jens H. Kuhn,Michael Moore,Shiwen Luo,Swee-Kee Wong,I-Chueh Huang,Keming Xu,Natalya Vasilieva,Akikazu Murakami,Yaqing He,Wayne A. Marasco,Yi Guan,Hyeryun Choe,Michael Farzan +17 more
TL;DR: Comparisons of S proteins of SARS‐CoV isolated during the 2002–2003 SARS outbreak and during the much less severe 2003–2004 outbreak, and from palm civets, provide insight into the severity of the 2002‐ 2003 SARS epidemic.
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A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2
TL;DR: It is demonstrated that a 193-amino acid fragment of the S protein bound ACE2 more efficiently than did the full S1 domain (residues 12–672) and a point mutation at aspartic acid 454 abolished association of the fullS1 domain and of the 193-residue fragment with ACE2.
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A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
Shengdong Ke,Endalkachew Ashenafi Alemu,Claudia Mertens,Emily Conn Gantman,John J. Fak,John J. Fak,Aldo Mele,Aldo Mele,Bhagwattie Haripal,Ilana Zucker-Scharff,Ilana Zucker-Scharff,Michael Moore,Michael Moore,Christopher Y. Park,Cathrine Broberg Vågbø,Anna Kusśnierczyk,Arne Klungland,Arne Klungland,James E. Darnell,Robert B. Darnell +19 more
TL;DR: It is found that m(6)A density peaks early in the 3' UTR and that, among transcripts with alternative polyA (APA) usage in both the brain and the liver, brain transcripts preferentially use distal polyA sites, as reported, and also show higher proximal m( 6)Adensity in the last exons.
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Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
Jianhua Sui,Wenhui Li,Akikazu Murakami,Azaibi Tamin,Leslie J. Matthews,Swee Kee Wong,Michael Moore,Aimee St. Clair Tallarico,Mobolaji Olurinde,Hyeryun Choe,Larry J. Anderson,William J. Bellini,Michael Farzan,Wayne A. Marasco +13 more
TL;DR: Data suggest that the 80R human monoclonal antibody may be a useful viral entry inhibitor for the emergency prophylaxis and treatment of SARS, and that the ACE2-binding site of S1 could be an attractive target for subunit vaccine and drug development.