Author
Michael. Orange
Bio: Michael. Orange is an academic researcher from Jewish Hospital. The author has contributed to research in topics: Magnesium. The author has an hindex of 1, co-authored 1 publications receiving 209 citations.
Topics: Magnesium
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209 citations
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DOI•
20 Nov 2006
TL;DR: 原发性醛固酮瘤及其主要的病理亚型, 为影像学检查的补充.
Abstract: 原发性醛固酮增多症(原醛症)是继发性高血压的常见病因之一,部分患者亦可伴有低血钾,醛固酮瘤及特发性醛固酮增多症是其主要的病理亚型.原醛症的诊断包括筛查、确诊及分型诊断3个步骤,传统影像学结合体位刺激的方法进行分型诊断,假阳性及假阴性率均较高,肾上腺静脉插管采血可作为影像学检查的补充.醛固酮瘤及原发性肾上腺增生患者应予手术治疗,特发性醛固酮增多症患者多采用药物治疗,螺内酯是其首选药物。
337 citations
144 citations
TL;DR: Alkaline phosphatase prepared from human placentae shows greater resistance to heat inactivation than any other known alkalineosphatase of human origin and this heat stability is seen in freshly prepared enzyme, in alcohol-fractionated and freeze-dried material, and in the sera of individuals into whom placental alkaline phosphate has been infused.
Abstract: Alkaline phosphatase prepared from human placentae shows greater resistance to heat inactivation than any other known alkaline phosphatase of human origin. In the presence of magnesium this enzyme may be heated at 70°C. for 30 minutes without loss of activity whereas other human alkaline phosphatases lose most of their activity on being heated at 56°C. for this period of time. This heat stability is seen in freshly prepared enzyme, in alcohol-fractionated and freeze-dried material, and in the sera of individuals into whom placental alkaline phosphatase has been infused. The clinical implications of our observations are briefly indicated.
126 citations
TL;DR: Treatment of mitochondria with deoxycholate solutions of varying strengths resulted in a gradual and reproducible disintegration of the mitochondria and produced a characteristic release of Mg ++ and of material absorbing maximally at 260 mμ from the mitochondia.
125 citations
113 citations