M
Michael P. Cooke
Researcher at Novartis
Publications - 46
Citations - 7575
Michael P. Cooke is an academic researcher from Novartis. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 15, co-authored 46 publications receiving 7292 citations.
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Journal ArticleDOI
A gene atlas of the mouse and human protein-encoding transcriptomes
Andrew I. Su,Tim Wiltshire,Serge Batalov,Hilmar Lapp,Keith A. Ching,David Block,Jie Zhang,Richard Soden,Mimi Hayakawa,Gabriel Kreiman,Gabriel Kreiman,Michael P. Cooke,John R. Walker,John B. Hogenesch,John B. Hogenesch +14 more
TL;DR: In this paper, high-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale, and the authors have designed custom arrays that interrogate the expression of the vast majority of proteinencoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues.
Journal ArticleDOI
Large-scale analysis of the human and mouse transcriptomes
Andrew I. Su,Michael P. Cooke,Keith A. Ching,Yaron Hakak,John R. Walker,Tim Wiltshire,Anthony P. Orth,Raquel Vega,Lisa M. Sapinoso,Aziz Moqrich,Ardem Patapoutian,Garret M. Hampton,Peter G. Schultz,Peter G. Schultz,John B. Hogenesch +14 more
TL;DR: This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics.
Journal ArticleDOI
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Anthony E. Boitano,Jian Wang,Russell Romeo,Laure C. Bouchez,Albert E. Parker,Sue E. Sutton,John R. Walker,Colin A. Flaveny,Gary H. Perdew,Michael S. Denison,Peter G. Schultz,Michael P. Cooke +11 more
TL;DR: Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR) and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.
Journal ArticleDOI
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Koichi Tabeta,Kasper Hoebe,Edith M. Janssen,Xin Du,Philippe Georgel,Karine Crozat,Suzanne Mudd,Navjiwan Mann,Sosathya Sovath,Jason Goode,Louis Shamel,Anat A. Herskovits,Daniel A. Portnoy,Michael P. Cooke,Lisa M. Tarantino,Tim Wiltshire,Benjamin E. Steinberg,Sergio Grinstein,Bruce Beutler +18 more
TL;DR: 'triple D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9, suggests communication between these organellar systems.
Journal ArticleDOI
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
Tim Wiltshire,Mathew T. Pletcher,Serge Batalov,S. Whitney Barnes,Lisa M. Tarantino,Michael P. Cooke,Hua Wu,Kevin J. Smylie,Andrey Santrosyan,Neal G. Copeland,Nancy A. Jenkins,Francis Kalush,Richard J. Mural,Richard Glynne,Steve A. Kay,Mark Raymond Adams,Colin F. Fletcher,Colin F. Fletcher +17 more
TL;DR: This work examines the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice to gain insight into the genetic and evolutionary factors influencing such biological variation.