M
Michael P. Waalkes
Researcher at National Institutes of Health
Publications - 292
Citations - 21209
Michael P. Waalkes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cadmium & Metallothionein. The author has an hindex of 80, co-authored 292 publications receiving 19946 citations. Previous affiliations of Michael P. Waalkes include Research Triangle Park.
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Journal ArticleDOI
Cadmium carcinogenesis in review.
TL;DR: Cadmium inhalation in rats results in pulmonary adenocarcinomas, supporting a role in human lung cancer, and various treatments can modify cadmium carcinogenesis including supplemental zinc, which prevents Cadmium-induced injection site and testicular tumors while facilitating prostatic tumors.
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Arsenic: health effects, mechanisms of actions, and research issues.
C O Abernathy,Y P Liu,D Longfellow,H V Aposhian,B Beck,Bruce A. Fowler,Robert A. Goyer,R Menzer,T Rossman,Claudia Thompson,Michael P. Waalkes +10 more
TL;DR: A meeting on the health effects of arsenic (As), its modes of action, and areas in need of future research was held in Hunt Valley, Maryland, on 22-24 September 1997, and the most important areas cited were As metabolism and its interaction with cellular constituents and possible bioaccumulation.
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Association of Arsenic-Induced Malignant Transformation with DNA Hypomethylation and Aberrant Gene Expression
Christopher Q. Zhao,Matthew R. Young,Bhalchandra A. Diwan,Timothy P. Coogan,Michael P. Waalkes +4 more
TL;DR: Results indicate arsenic can act as a carcinogen by inducing DNA hypomethylation, which in turn facilitates aberrant gene expression, and they constitute a tenable theory of mechanism in arsenic carcinogenesis.
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Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
TL;DR: Results indicate that, while cadmium is an effective inhibitor of DNA MeTase and initially induces DNA hypomethylation, prolonged exposure results in DNA hypermethylation and enhanced DNA Me tase activity.
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Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice.
TL;DR: It is demonstrated that oral inorganic arsenic exposure, as a single agent, can induce tumor formation in rodents and establishes in organic arsenic as a complete transplacental carcinogen in mice.