M
Michael R. H. White
Researcher at University of Manchester
Publications - 148
Citations - 8393
Michael R. H. White is an academic researcher from University of Manchester. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 46, co-authored 143 publications receiving 7673 citations. Previous affiliations of Michael R. H. White include University of Oxford & University of Liverpool.
Papers
More filters
Journal ArticleDOI
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
David E. Nelson,Adaoha E. C. Ihekwaba,M Elliott,James R. Johnson,C. A. Gibney,B. E. Foreman,Glyn Nelson,Violaine Sée,Caroline A. Horton,David G. Spiller,Steven W. Edwards,H. P. McDowell,John Unitt,Elaine Sullivan,Rachel L. Grimley,Neil Benson,David S. Broomhead,Douglas B. Kell,Michael R. H. White +18 more
TL;DR: Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription.
Journal ArticleDOI
Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription
Louise Ashall,Caroline A. Horton,David E. Nelson,Pawel Paszek,Claire V. Harper,Kate Sillitoe,Sheila Ryan,David G. Spiller,John Unitt,David S. Broomhead,Douglas B. Kell,David A. Rand,Violaine Sée,Michael R. H. White +13 more
TL;DR: Altering the stimulation intervals gave different patterns of NF-κB–dependent gene expression, which supports the idea that oscillation frequency has a functional role in nuclear factor κB regulation.
Journal ArticleDOI
Measurement of single-cell dynamics.
TL;DR: Multiparameter experimental and computational methods that integrate quantitative measurement and mathematical simulation of these noisy and complex processes are required to understand the highly dynamic mechanisms that control cell plasticity and fate.
Journal ArticleDOI
The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis.
Gianluca Fossati,Dale Moulding,David G. Spiller,Robert J. Moots,Michael R. H. White,Steven W. Edwards +5 more
TL;DR: Observations indicate that intact mitochondrial function is required to sustain some neutrophil functions, but not for the rapid initiation of the respiratory burst or phagocytosis, as previously reported.
Journal ArticleDOI
Characterization of the ethanol-inducible alc gene-expression system in Arabidopsis thaliana.
Hairul Azman Roslan,Michael G. Salter,Christopher D. Wood,Michael R. H. White,Kevan P. Croft,Frances Robson,George Coupland,John H. Doonan,Patrick Laufs,A. Brian Tomsett,Mark X. Caddick +10 more
TL;DR: It is demonstrated that alcR-mediated expression occurs throughout the plant in a highly responsive manner, and optimal strategies for utilizing the alc system in A. thaliana are described.