Author
Michael R. Petersen
Bio: Michael R. Petersen is an academic researcher from Scripps Institution of Oceanography. The author has contributed to research in topics: Claisen rearrangement & Carroll rearrangement. The author has an hindex of 4, co-authored 7 publications receiving 664 citations.
Papers
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561Â citations
69Â citations
TL;DR: Faulkner and Petersen as discussed by the authors described a simple and convenient route to trans-trisubstituted olefinic bonds, employing highly stereoselective examples of the Claisen rearrangement.
26Â citations
TL;DR: Analytical determinations have been made of the levels of insect juvenile hormone from male and female Hyalophora cecropia by combined gas chromatographymass spectrometry with continuous recording of the intensities of two rearrangement ions from the parent molecules.
19Â citations
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753Â citations
391Â citations
TL;DR: This paper shows by example some total syntheses which draw from strategy-enabling advances in methodology and shows how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.
Abstract: Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.
322Â citations
273Â citations
229Â citations