M
Michael R. Wasserman
Researcher at Rockefeller University
Publications - 28
Citations - 2644
Michael R. Wasserman is an academic researcher from Rockefeller University. The author has contributed to research in topics: Translation (biology) & Eukaryotic Ribosome. The author has an hindex of 14, co-authored 24 publications receiving 2152 citations. Previous affiliations of Michael R. Wasserman include Cornell University & Harvard University.
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Journal ArticleDOI
Physical forces during collective cell migration
Xavier Trepat,Xavier Trepat,Michael R. Wasserman,Thomas E. Angelini,Emil Millet,David A. Weitz,James P. Butler,Jeffrey J. Fredberg +7 more
TL;DR: These unexpected findings demonstrate that although the leader cell may have a pivotal role in local cell guidance, physical forces that it generates are but a small part of a global tug-of-war involving cells well back from the leading edge.
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Ultra-stable organic fluorophores for single-molecule research
Qinsi Zheng,Manuel F. Juette,Steffen Jockusch,Michael R. Wasserman,Zhou Zhou,Roger B. Altman,Scott C. Blanchard +6 more
TL;DR: Self-healing organic fluorophores, wherein the triplet state is intramolecularly quenched by a covalently attached protective agent, exhibit markedly improved photostabilities and are likely to impact the future of single-molecule research.
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Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale
Manuel F. Juette,Daniel S. Terry,Michael R. Wasserman,Roger B. Altman,Zhou Zhou,Hong Zhao,Scott C. Blanchard +6 more
TL;DR: A single-molecule imaging and analysis platform using scientific complementary metal-oxide semiconductor (sCMOS) detectors that enables imaging of 15,000 individual molecules simultaneously at millisecond rates enabled the detection of previously obscured processes relevant to the fidelity mechanism in protein synthesis.
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High-resolution structure of the Escherichia coli ribosome.
Jonas Noeske,Michael R. Wasserman,Daniel S. Terry,Roger B. Altman,Scott C. Blanchard,Jamie H. D. Cate +5 more
TL;DR: The structure of the Escherichia coli 70S ribosome is presented at 2.4-Å resolution and reveals details of the ribosomal subunit interface that are conserved in all domains of life, and it suggests how solvation contributes to ribosomes integrity and function as well as how the conformation of Ribosomal protein uS12 aids in mRNA decoding.
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Allosteric control of the ribosome by small-molecule antibiotics.
Leyi Wang,Arto Pulk,Michael R. Wasserman,Michael Feldman,Roger B. Altman,Jamie H. D. Cate,Jamie H. D. Cate,Scott C. Blanchard +7 more
TL;DR: Findings reveal the functional importance of reversible intersubunit rotation to the translation mechanism and shed new light on the allosteric control of ribosome functions by small-molecule antibiotics.