M
Michael S. Cuoco
Researcher at Broad Institute
Publications - 34
Citations - 3698
Michael S. Cuoco is an academic researcher from Broad Institute. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 15, co-authored 28 publications receiving 1607 citations. Previous affiliations of Michael S. Cuoco include University of California, San Diego & Harvard University.
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Journal ArticleDOI
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon,Parin Shah,Michael S. Cuoco,Christopher Rodman,Mei-Ju Su,Johannes C. Melms,Rachel Leeson,Abhay Kanodia,Shaolin Mei,Jia-Ren Lin,Shu Wang,Bokang Rabasha,David Liu,Gao Zhang,Claire Margolais,Orr Ashenberg,Patrick A. Ott,Elizabeth I. Buchbinder,Rizwan Haq,F. Stephen Hodi,Genevieve M. Boland,Ryan J. Sullivan,Dennie T. Frederick,Benchun Miao,Tabea Moll,Keith T. Flaherty,Meenhard Herlyn,Russell W. Jenkins,Rohit Thummalapalli,Monika S. Kowalczyk,Israel Cañadas,Bastian Schilling,Bastian Schilling,Adam N.R. Cartwright,Adrienne M. Luoma,Shruti Malu,Patrick Hwu,Chantale Bernatchez,Marie Andrée Forget,David A. Barbie,Alex K. Shalek,Itay Tirosh,Peter K. Sorger,Kai W. Wucherpfennig,Eliezer M. Van Allen,Dirk Schadendorf,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Levi A. Garraway,Charles H. Yoon,Charles H. Yoon,Benjamin Izar,Aviv Regev +54 more
TL;DR: A resistance program expressed by malignant cells that is associated with T cell exclusion and immune evasion is identified, and this study provides a high-resolution landscape of ICI-resistant cell states, identifies clinically predictive signatures, and suggests new therapeutic strategies to overcome immunotherapy resistance.
Journal ArticleDOI
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Antonia Wallrapp,Samantha J. Riesenfeld,Patrick R. Burkett,Raja-Elie E. Abdulnour,Jackson Nyman,Danielle Dionne,Matan Hofree,Michael S. Cuoco,Christopher Rodman,Daneyal Farouq,Brian J. Haas,Timothy L. Tickle,John J. Trombetta,Pankaj Baral,Christoph S.N. Klose,Tanel Mahlakõiv,David Artis,Orit Rozenblatt-Rosen,Isaac M. Chiu,Bruce D. Levy,Monika S. Kowalczyk,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +24 more
TL;DR: In this paper, the authors profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33.
Journal ArticleDOI
The Human and Mouse Enteric Nervous System at Single-Cell Resolution.
Eugene Drokhlyansky,Christopher Smillie,Nicholas Van Wittenberghe,Maria Ericsson,Gabriel K. Griffin,Gabriel K. Griffin,Gökcen Eraslan,Danielle Dionne,Michael S. Cuoco,Max N. Goder-Reiser,Tatyana Sharova,Olena Kuksenko,Andrew J. Aguirre,Andrew J. Aguirre,Genevieve M. Boland,Daniel B. Graham,Daniel B. Graham,Orit Rozenblatt-Rosen,Ramnik J. Xavier,Aviv Regev,Aviv Regev +20 more
TL;DR: Two methods to profile the ENS of adult mice and humans at single-cell resolution are developed: RAISIN RNA-seq for profiling intact nuclei with ribosome-bound mRNA and MIRACL- sequencing for label-free enrichment of rare cell types by droplet-based profiling.
Posted ContentDOI
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Pascal Barbry,Christoph Muus,Christoph Muus,Malte D Luecken,Gökcen Eraslan,Avinash Waghray,Graham Heimberg,Lisa Sikkema,Yoshihiko Kobayashi,Eeshit Dhaval Vaishnav,Ayshwarya Subramanian,Christopher Smilie,Karthik A. Jagadeesh,Elizabeth Thu Duong,Evgenij Fiskin,Elena Torlai Triglia,Meshal Ansari,Peiwen Cai,Brian M. Lin,Justin Buchanan,Sijia Chen,Jian Shu,Jian Shu,Adam L. Haber,Adam L. Haber,Hattie Chung,Daniel T. Montoro,Taylor Adams,Hananeh Aliee,J. Samuel,Allon Zaneta Andrusivova,Ilias Angelidis,Orr Ashenberg,Kevin Bassler,Christophe Bécavin,Inbal Benhar,Joseph Bergenstråhle,Ludvig Bergenstråhle,Liam Bolt,Emelie Braun,Linh T. Bui,Mark Chaffin,Evgeny Chichelnitskiy,Joshua Chiou,Thomas M. Conlon,Michael S. Cuoco,Marie Deprez,David Fischer,Astrid Gillich,Joshua Gould,Minzhe Guo,Austin J. Gutierrez,Arun C. Habermann,Tyler Harvey,Peng He,Xiaomeng Hou,Xiaomeng Hou,Lijuan Hu,Alok Jaiswal,Peiyong Jiang,Theodoros Kapellos,Christin S. Kuo,Ludvig Larsson,Michael Leney-Greene,Kyungtae Lim,Monika Litviňuková,Monika Litviňuková,Ji Lu,Leif S. Ludwig,Wendy Luo,Henrike Maatz,Elo Madissoon,Lira Mamanova,Kasidet Manakongtreecheep,Kasidet Manakongtreecheep,Charles-Hugo Marquette,Ian Mbano,Alexi McAdams,Ross J. Metzger,Ahmad N. Nabhan,Sarah K. Nyquist,Lolita Penland,Olivier Poirion,Sergio Poli,Cancan Qi,Rachel Queen,Daniel Reichart,Daniel Reichart,Ivan O. Rosas,Jonas C. Schupp,Rahul Sinha,Rene Sit,Kamil Slowikowski,Kamil Slowikowski,Michal Slyper,Neal Smith,Neal Smith,Alex Sountoulidis,Maximilian Strunz,Dawei Sun,Carlos Talavera-López,Peng Tan,Jessica Tantivit,Jessica Tantivit,Kyle J. Travaglini,Nathan R. Tucker,Katherine A. Vernon,Katherine A. Vernon,Marc Wadsworth,Julia Waldman,Xiuting Wang,Wenjun Yan,William Zhao,Carly Ziegler +113 more
TL;DR: Differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.
Journal ArticleDOI
A single-cell landscape of high-grade serous ovarian cancer.
Benjamin Izar,Itay Tirosh,Elizabeth H. Stover,Isaac Wakiro,Michael S. Cuoco,Idan Alter,Christopher Rodman,Rachel Leeson,Mei-Ju Su,Parin Shah,Marcin P. Iwanicki,Sarah R. Walker,Abhay Kanodia,Johannes C. Melms,Shaolin Mei,Jia-Ren Lin,Caroline B. M. Porter,Michal Slyper,Julia Waldman,Livnat Jerby-Arnon,Orr Ashenberg,Titus J. Brinker,Caitlin E. Mills,Meri Rogava,Sébastien Vigneau,Peter K. Sorger,Levi A. Garraway,Panagiotis A. Konstantinopoulos,Joyce F. Liu,Ursula A. Matulonis,Bruce E. Johnson,Orit Rozenblatt-Rosen,Asaf Rotem,Asaf Rotem,Aviv Regev +34 more
TL;DR: Significant inter-patient variability is found in the composition and functional programs of ascites cells, including immunomodulatory fibroblast sub-populations and dichotomous macrophage populations, which contributes to resolving the HSGOC landscape and provides a resource for the development of novel therapeutic approaches.