Michael S. Wiesener

TL;DR: It is indicated that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF α-subunits, which may underlie the angiogenic phenotype of VHL-associated tumours.

TL;DR: Data indicate that Hif‐2 plays an important role in the transcriptional response to hypoxia in vivo, which is not confined to the vasculature and is complementary to rather than redundant with HIF‐1.

TL;DR: In this paper, high-amplification immunohistochemical analyses were used to study the expression of HIF-1alpha and -2alpha in kidneys of rats exposed to systemic hypoxia bleeding anemia, functional anemia (01% carbon monoxide), renal ischemia, or cobaltous chloride (which is known to mimic hyperoxia) and showed that these treatments led to marked nuclear accumulation of these transcription factors in different renal cell populations.

TL;DR: A remarkably restricted target gene specificity of the HIFα subunits is found, which can be overcome in cells with perturbations in the pVHL/HIF system and under forced expression.

TL;DR: The data indicate that HIF-1α and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen.