M
Michael Simons
Researcher at Yale University
Publications - 401
Citations - 41600
Michael Simons is an academic researcher from Yale University. The author has contributed to research in topics: Angiogenesis & Signal transduction. The author has an hindex of 106, co-authored 401 publications receiving 38071 citations. Previous affiliations of Michael Simons include Dartmouth–Hitchcock Medical Center & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Mosaic organization of DNA nucleotides
Chung-Kang Peng,Chung-Kang Peng,Chung-Kang Peng,Sergey V. Buldyrev,Sergey V. Buldyrev,Sergey V. Buldyrev,Shlomo Havlin,Shlomo Havlin,Shlomo Havlin,Michael Simons,Michael Simons,Michael Simons,H. E. Stanley,H. E. Stanley,H. E. Stanley,Ary L. Goldberger,Ary L. Goldberger,Ary L. Goldberger +17 more
TL;DR: This work analyzes two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations, finding that both types of sequences are quantitatively distinguishable by an alternative fluctuation analysis method.
Journal ArticleDOI
Long-range correlations in nucleotide sequences
Chung-Kang Peng,Sergey V. Buldyrev,Ary L. Goldberger,Shlomo Havlin,Shlomo Havlin,Francesco Sciortino,Michael Simons,Michael Simons,H. E. Stanley +8 more
TL;DR: This work proposes a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which it refers to as a 'DNA walk', and uncovers a remarkably long-range power law correlation.
Journal ArticleDOI
Mechanisms and regulation of endothelial VEGF receptor signalling
TL;DR: A clear understanding of the tight and multi-level regulation of VEGFR2 signalling is key to successful therapeutic suppression or stimulation of vascular growth.
Journal ArticleDOI
Antisense c- myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
Michael Simons,Michael Simons,Elazer R. Edelman,Jean-Luc Dekeyser,Robert Langer,Robert D. Rosenberg,Robert D. Rosenberg +6 more
TL;DR: The use of local delivery of antisense c-myb oligonu-cleotide to suppress intimal accumulation of rat carotid arterial smooth muscle cells is reported to suggest that antisense oligonucleotides can be used to define the in vivo biological role of specific macromolecules in the blood vessel wall.
Journal ArticleDOI
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone,Massimiliano Mazzone,Daniela Dettori,Daniela Dettori,Daniela Dettori,Rodrigo Leite de Oliveira,Rodrigo Leite de Oliveira,Sonja Loges,Sonja Loges,Thomas Schmidt,Thomas Schmidt,Bart Jonckx,Bart Jonckx,Ya Min Tian,Anthony A. Lanahan,Patrick J. Pollard,Carmen Ruiz de Almodovar,Carmen Ruiz de Almodovar,Frederik De Smet,Frederik De Smet,Stefan Vinckier,Stefan Vinckier,Julián Aragonés,Julián Aragonés,Koen Debackere,Koen Debackere,Aernout Luttun,Sabine Wyns,Sabine Wyns,Bénédicte F. Jordan,Alberto Pisacane,Bernard Gallez,Maria Grazia Lampugnani,Elisabetta Dejana,Michael Simons,Peter J. Ratcliffe,Patrick H. Maxwell,Peter Carmeliet,Peter Carmeliet +38 more
TL;DR: In this paper, the role of endothelial PHD2 in vessel shaping by implanting tumors in mice was investigated. But, the authors did not find that PHD deficiency did not affect vessel density or lumen size.