Michael Snyder

TL;DR: It is concluded that human iPSCs are capable of replacing SCNT for generating differentiated cells for drug testing and disease modeling and can replace nt-ESCs as alternatives for generating patient-specific differentiation cells for disease modeled and preclinical drug testing.

TL;DR: This unit describes ChIP‐Seq methodology, which involves chromatin immunoprecipitation (ChIP) followed by high‐throughput sequencing (Seq), and enables the genome‐wide identification of binding sites of transcription factors (TFs) and other DNA‐binding proteins.

TL;DR: The data provide evidence for an evolutionarily conserved mechanism by which lipid metabolites can orchestrate transcription in a yeast system and propose a model in which the START domain is used by both plants and mammals to regulate transcription factor activity.

TL;DR: This global investigation of proteins that interact with the majority of yeast protein kinases using protein microarrays indicates that kinases operate in a highly interconnected network that coordinates many activities of the proteome.

TL;DR: A modified method for chromatin immunoprecipitation and deep sequencing (ChIP–Seq) is used and its use to construct a high-resolution map of the Drosophila melanogaster key histone marks, heterochromatin protein 1a (HP1a) and RNA polymerase II (polII) reveals fundamental features of chromatin modification landscape shared by major adult Drosophile cell types.