M
Michael Snyder
Researcher at Stanford University
Publications - 938
Citations - 150929
Michael Snyder is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 169, co-authored 840 publications receiving 130225 citations. Previous affiliations of Michael Snyder include Wyss Institute for Biologically Inspired Engineering & Public Health Research Institute.
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Journal ArticleDOI
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Miller Huang,Jignesh Tailor,Qiqi Zhen,Aaron Gillmor,Aaron Gillmor,Matthew L. Miller,Holger Weishaupt,Justin Chen,Tina Zheng,Emily K. Nash,Lauren K. McHenry,Z. H. An,Fubaiyang Ye,Yasuhiro Takashima,James Clarke,Harold Ayetey,Florence M.G. Cavalli,Betty Luu,Branden S. Moriarity,Shirin Ilkhanizadeh,Lukas Chavez,Chunying Yu,Kathreena M Kurian,Thierry Magnaldo,Nicolas Sevenet,Philipp Koch,Philipp Koch,Steven M. Pollard,Peter B. Dirks,Michael Snyder,David A. Largaespada,Yoon Jae Cho,Joanna J. Phillips,Fredrik J. Swartling,A. Sorana Morrissy,Marcel Kool,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor,Austin Smith,William A. Weiss +40 more
TL;DR: It is demonstrated that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma, and candidate cooperating mutations in Gorlin NES cells are engineered to accelerate tumorigenesis.
Journal ArticleDOI
Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension.
Armando Reyes-Palomares,Mingxia Gu,Fabian Grubert,Ivan Berest,Silin Sa,Maya Kasowski,Christian Arnold,Mao Shuai,Rohith Srivas,Simon Miao,Dan Li,Michael Snyder,Marlene Rabinovitch,Judith B. Zaugg +13 more
TL;DR: It is predicted that primed enhancers in PAH PAECs are activated by the differentially active TFs, resulting in an aberrant response to endothelial signals, which could lead to disturbed angiogenesis and endothelial-to-mesenchymal-transition.
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Comparative annotation of functional regions in the human genome using epigenomic data.
TL;DR: A machine-learning method called ChroModule is developed to annotate the epigenetic states in eight ENCyclopedia Of DNA Elements cell types and it is found that invariable and variable epigeneticStates across cell types correspond to housekeeping functions and stimulus response, respectively.
Journal ArticleDOI
Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1
Nils Landegren,Donald Sharon,Donald Sharon,Eva Freyhult,Åsa Hallgren,Åsa Hallgren,Daniel Eriksson,Daniel Eriksson,Per-Henrik Edqvist,Sophie Bensing,Jeanette Wahlberg,Lawrence M. Nelson,Jan Gustafsson,Eystein S. Husebye,Mark S. Anderson,Michael Snyder,Olle Kämpe,Olle Kämpe +17 more
TL;DR: It is suggested that only a very limited portion of the proteome becomes targeted by the immune system in APS1, which contrasts the broad defect of thymic presentation associated with AIRE-deficiency and raises novel questions what other factors are needed for break of tolerance.
Journal Article
Ursodiol Prophylaxis against Hepatic Complications of Allogeneic Bone Marrow Transplantation
James Essell,Mark T. Schroeder,Glenn S. Harman,Ronald Halvorson,Vernon Lew,Natalie S. Callander,Michael Snyder,Stacey K. Lewis,Jeffrey P. Allerton,James M. Thompson +9 more
TL;DR: A randomized, double-blind, placebo-controlled study to confirm the reduction in hepatic complications seen with ursodiol prophylaxis in a pilot trial of veno-occlusive disease.