M
Michael Snyder
Researcher at Stanford University
Publications - 938
Citations - 150929
Michael Snyder is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 169, co-authored 840 publications receiving 130225 citations. Previous affiliations of Michael Snyder include Wyss Institute for Biologically Inspired Engineering & Public Health Research Institute.
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Journal ArticleDOI
Longitudinal personal DNA methylome dynamics in a human with a chronic condition
Rui Chen,Lin Xia,Kailing Tu,Meixue Duan,Kimberly R. Kukurba,Jennifer Li-Pook-Than,Dan Xie,Dan Xie,Michael Snyder +8 more
TL;DR: It is found that DNA methylomic changes are associated with infrequent glucose level alteration, whereas the transcriptome underwent dynamic changes during events such as viral infections, while most DNA meta-methylome changes occurred 80–90 days before clinically detectable glucose elevation.
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Evidence against a genomic code for nucleosome positioning. Reply to "Nucleosome sequence preferences influence in vivo nucleosome organization.".
Yong Zhang,Zarmik Moqtaderi,Barbara P. Rattner,Ghia Euskirchen,Michael Snyder,James T. Kadonaga,X. Shirley Liu,Kevin Struhl +7 more
TL;DR: Evidence against a genomic code for nucleosome positioning is presented and it is shown that sequence preferences influence in vivo nucleosomes organization.
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Cooperative transcription factor associations discovered using regulatory variation
Konrad J. Karczewski,Nicholas P. Tatonetti,Stephen G. Landt,Xinqiong Yang,Teri Slifer,Russ B. Altman,Michael Snyder +6 more
TL;DR: The Allele Binding Cooperativity test is described in detail, which uses variation in transcription factor binding among individuals to discover combinations of factors and their targets, and developed the ALPHABIT pipeline, which includes statistical analysis of binding sites followed by experimental validation.
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A transposable element that splits the promoter region inactivates a Drosophila cuticle protein gene.
Michael Snyder,Deborah A. Kimbrell,Michael W. Hunkapiller,Ron Hill,James W. Fristrom,Norman Davidson +5 more
TL;DR: Protein and DNA sequence analyses indicate that point mutations cause two amino acid substitutions that change the electrophoretic mobility of CPf2 relative to that of CP2, and insertion of a transposable element into the putative promoter region of the CP3 gene is evidently responsible for inactivatingCP3 gene expression.
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Yeast as a Model for Human Disease
Michael G. Smith,Michael Snyder +1 more
TL;DR: Yeast is a simple eukaryote with a tractable genome, a short generation time, and a large network of researchers who have generated a vast arsenal of research tools that make yeast ideally suited to help reveal the function of genes implicated in human disease.