M
Michael Spedding
Researcher at DuPont
Publications - 288
Citations - 30803
Michael Spedding is an academic researcher from DuPont. The author has contributed to research in topics: Receptor & Neuroprotection. The author has an hindex of 69, co-authored 278 publications receiving 28961 citations. Previous affiliations of Michael Spedding include École normale supérieure de Lyon & University of Maryland, Baltimore.
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Journal ArticleDOI
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
Journal ArticleDOI
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
Simon D. Harding,Joanna L. Sharman,Elena Faccenda,Christopher Southan,Adam J. Pawson,Sam M. Ireland,Alasdair J. G. Gray,Liam Bruce,Stephen P.H. Alexander,Stephen M. Anderton,Clare E. Bryant,Anthony P. Davenport,Christian Doerig,Doriano Fabbro,Francesca Levi-Schaffer,Michael Spedding,Jamie A. Davies,Nc-Iuphar +17 more
TL;DR: This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015, and introduces the newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org).
Journal ArticleDOI
A unified nomenclature system for the nuclear receptor superfamily
Johan Auwerx,E. Baulieu,Miguel Beato,M. Becker-Andre,P. H. Burbach,G. Camerino,P. Chambon,Austin J. Cooney,A. Dejean,C. Dreyer,Ronald M. Evans,Frank Gannon,Vincent Giguère,Hinrich Gronemeyer,Jan-Åke Gustafsson,Vincent Laudet,Mitchell A. Lazar,David J. Mangelsdorf,J. Millbrandt,E. Milgrom,David D. Moore,Bert W. O'Malley,M G Parker,K. Parker,T. Perimann,M. Pfahl,Michael G. Rosenfeld,H. Samuels,G. Schutz,Frances M. Sladek,Hendrik G. Stunnenberg,Michael Spedding,Carl S. Thummel,M. J. Tsai,K. Umesono,B. Vennstrom,Walter Wahli,C. Weinberg,Timothy M. Willson,K. Yamamoto +39 more
TL;DR: Over the last decade, workers in the field have described more than 300 sequences of NRs using an increasingly complex and baroque nomenclature, which constitutes a barrier for understanding of newly acquired knowledge to researchers outside as well as within the field.
Journal ArticleDOI
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
Jonathan D. Urban,William P. Clarke,Mark von Zastrow,David E. Nichols,Brian K. Kobilka,Harel Weinstein,Jonathan A. Javitch,Bryan L. Roth,Arthur Christopoulos,Patrick M. Sexton,Keith J. Miller,Michael Spedding,Richard B. Mailman +12 more
TL;DR: Besides the heuristically interesting nature of functional selectivity, there is a clear impact on drug discovery, because this mechanism raises the possibility of selecting or designing novel ligands that differentially activate only a subset of functions of a single receptor, thereby optimizing therapeutic action.
Journal ArticleDOI
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
Christopher Southan,Joanna L. Sharman,Helen E. Benson,Elena Faccenda,Adam J. Pawson,Stephen P.H. Alexander,Peter Buneman,Anthony P. Davenport,John C. McGrath,John C. McGrath,John A. Peters,Michael Spedding,William A. Catterall,Doriano Fabbro,Jamie A. Davies +14 more
TL;DR: The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) database provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome, and provides an expanded substrate for the biennially published compendium, the Concise Guide topharmacology.