M
Michael T. Laub
Researcher at Massachusetts Institute of Technology
Publications - 137
Citations - 16021
Michael T. Laub is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Caulobacter crescentus & Response regulator. The author has an hindex of 56, co-authored 137 publications receiving 14260 citations. Previous affiliations of Michael T. Laub include Harvard University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis
Elizabeth A. Winzeler,Daniel D. Shoemaker,Anna Astromoff,Hong Liang,Keith Anderson,Bruno André,Rhonda Bangham,Rocío Benito,Jef D. Boeke,Howard Bussey,Angela M. Chu,Carla Connelly,Karen Davis,Fred S. Dietrich,Sally Dow,Mohamed El Bakkoury,Françoise Foury,Stephen H. Friend,Erik Gentalen,Guri Giaever,Johannes H. Hegemann,Ted Jones,Michael T. Laub,Hong Liao,Nicole Liebundguth,David J. Lockhart,Anca Lucau-Danila,Marc Lussier,Nasiha M'Rabet,Patrice Menard,Michael Mittmann,Chai Pai,Corinne Rebischung,José L. Revuelta,Linda Riles,Christopher J. Roberts,Petra Ross-Macdonald,Bart Scherens,Michael Snyder,Sharon Sookhai-Mahadeo,Reginald Storms,Steeve Veronneau,Marleen Voet,Guido Volckaert,Teresa R. Ward,Robert W. Wysocki,Grace Yen,Kexin Yu,Katja Zimmermann,Peter Philippsen,Mark Johnston,Ronald W. Davis +51 more
TL;DR: A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome), finding that 17 percent were essential for viability in rich medium.
Journal ArticleDOI
Specificity in Two-Component Signal Transduction Pathways
Michael T. Laub,Mark Goulian +1 more
TL;DR: The cellular and molecular mechanisms that dictate the specificity of two-component signaling pathways are reviewed, including the role of phosphoryl group transfer, which can then effect changes in cellular physiology, often by regulating gene expression.
Journal ArticleDOI
Evolution of Two-Component Signal Transduction Systems
Emily J. Capra,Michael T. Laub +1 more
TL;DR: Progress made in answering questions about the molecular basis by which two-component proteins evolve is reviewed, highlighting how the integration of genome sequence data with experimental studies is providing major new insights.
Journal ArticleDOI
Complete genome sequence of Caulobacter crescentus.
William C. Nierman,Tamara Feldblyum,Michael T. Laub,Ian T. Paulsen,Karen E. Nelson,Jonathan A. Eisen,John F. Heidelberg,M. R. K. Alley,Noriko Ohta,Janine R. Maddock,Isabel Potocka,William C. Nelson,Austin Newton,Craig Stephens,Nikhil D. Phadke,Bert Ely,Robert T. DeBoy,Robert J. Dodson,A. Scott Durkin,Michelle L. Gwinn,Daniel H. Haft,James F. Kolonay,John Smit,M. B. Craven,Hoda Khouri,Jyoti Shetty,Kristi Berry,Teresa Utterback,Kevin Tran,Alex M. Wolf,Jessica Vamathevan,Maria D. Ermolaeva,Owen White,Steven L. Salzberg,J. Craig Venter,J. Craig Venter,Lucy Shapiro,Claire M. Fraser +37 more
TL;DR: C. crescentus is, to the authors' knowledge, the first free-living α-class proteobacterium to be sequenced and will serve as a foundation for exploring the biology of this group of bacteria, which includes the obligate endosymbiont and human pathogen Rickettsia prowazekii, the plant pathogen Agrobacterium tumefaciens, and the bovine andhuman pathogen Brucella abortus.
Journal ArticleDOI
High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome
TL;DR: Analysis of Hi-C data and polymer modeling indicates that the Caulobacter crescentus chromosome consists of multiple, largely independent spatial domains that are probably composed of supercoiled plectonemes arrayed into a bottle brush–like fiber, and general principles for the organization and structure of chromosomes in vivo are revealed.