M
Michael V. Tullius
Researcher at University of California, Los Angeles
Publications - 23
Citations - 1193
Michael V. Tullius is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Mycobacterium tuberculosis & Haemophilus ducreyi. The author has an hindex of 15, co-authored 23 publications receiving 1083 citations. Previous affiliations of Michael V. Tullius include University of California, Irvine & University of California.
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Journal ArticleDOI
Discovery and characterization of a unique mycobacterial heme acquisition system.
Michael V. Tullius,Christine A. Harmston,Cedric P. Owens,Nicholas Chim,Robert P. Morse,Lisa M. McMath,Angelina Iniguez,Jacqueline M. Kimmey,Michael R. Sawaya,Julian P. Whitelegge,Marcus A. Horwitz,Celia W. Goulding +11 more
TL;DR: Key players of this heme uptake system were characterized including a secreted protein and two transmembrane proteins, all three specific to mycobacteria, and the crystal structure of the key heme carrier protein Rv0203 was found to have a unique fold.
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Glutamine Synthetase GlnA1 Is Essential for Growth of Mycobacterium tuberculosis in Human THP-1 Macrophages and Guinea Pigs
TL;DR: It is demonstrated that glnA1 is essential for M. tuberculosis virulence, and this strain was virulent in guinea pigs, although somewhat less so than the wild-type.
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All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
TL;DR: The generation of mutants in M. tuberculosis of the four glnA genes, murD and murI demonstrated that all of these genes except gln a1 are nonessential for in vitro growth.
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High Extracellular Levels of Mycobacterium tuberculosis Glutamine Synthetase and Superoxide Dismutase in Actively Growing Cultures Are Due to High Expression and Extracellular Stability Rather than to a Protein-Specific Export Mechanism
TL;DR: These findings indicate that, contrary to expectations, export of M. tuberculosis GS and SOD in actively growing cultures is not due to a protein-specific export mechanism, but rather to bacterial leakage or autolysis, and that the extracellular abundance of these enzymes is simply due to their high level of expression andextracellular stability.
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A Replication-Limited Recombinant Mycobacterium bovis BCG Vaccine against Tuberculosis Designed for Human Immunodeficiency Virus-Positive Persons Is Safer and More Efficacious than BCG
TL;DR: This study demonstrates the feasibility of developing safer and more potent vaccines against tuberculosis and engineering a replication-limited vaccine expressing a recombinant immunoprotective antigen and preloading it with a required nutrient, such as iron, that is capable of being stored should be generally applicable to other live vaccine vectors targeting intracellular pathogens.