M
Michael W. Graner
Researcher at Anschutz Medical Campus
Publications - 108
Citations - 9335
Michael W. Graner is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Microvesicles & Heat shock protein. The author has an hindex of 39, co-authored 92 publications receiving 7359 citations. Previous affiliations of Michael W. Graner include University of Arizona & University of Colorado Denver.
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Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
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Mutant Epidermal Growth Factor Receptor (EGFRvIII) Contributes to Head and Neck Cancer Growth and Resistance to EGFR Targeting
John C. Sok,Francesca M. Coppelli,Sufi M. Thomas,Miriam N. Lango,Sichuan Xi,Jennifer L. Hunt,Maria L. Freilino,Michael W. Graner,Carol J. Wikstrand,Darell D. Bigner,William E. Gooding,Frank B. Furnari,Jennifer R. Grandis +12 more
TL;DR: EGFRvIII is expressed in HNSCC where it contributes to enhanced growth and resistance to targeting wild-type EGFR, and the antitumor efficacy of EGFR targeting strategies may be enhanced by the addition of EG FRvIII-specific blockade.
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Biodistribution and delivery efficiency of unmodified tumor-derived exosomes.
Tyson Smyth,Max Kullberg,Noeen Malik,Peter Smith-Jones,Michael W. Graner,Thomas J. Anchordoquy +5 more
TL;DR: Comparisons to liposomal formulations revealed the significance of the innate immune system along with the complement protein C5 on exosomes' rate of clearance and biodistribution, and limits their use as an anti-cancer drug delivery vehicle.
Journal ArticleDOI
Proteomic and immunologic analyses of brain tumor exosomes
Michael W. Graner,Oscar Alzate,Angelika M. Dechkovskaia,Jack D. Keene,John H. Sampson,Duane Mitchell,Darell D. Bigner +6 more
TL;DR: Exosomes released from brain tumor cells are biochemically/biophysically like other exosomes and have immune‐modulating properties and can escape the blood‐brain barrier’ with potential systemic and distal signaling and immune consequences.
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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules
Anand Ramteke,Harold Ting,Chapla Agarwal,Chapla Agarwal,Samiha Mateen,Ranganathan Somasagara,Anowar Hussain,Michael W. Graner,Barbara Frederick,Barbara Frederick,Rajesh Agarwal,Rajesh Agarwal,Gagan Deep,Gagan Deep +13 more
TL;DR: The findings suggest that ExoHypoxic are loaded with unique proteins that could enhance invasiveness, stemness, and induce microenvironment changes; thereby, promoting PCA aggressiveness.