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Michalina Bartak

Bio: Michalina Bartak is an academic researcher from Warsaw University of Life Sciences. The author has contributed to research in topics: Actin & Cell migration. The author has an hindex of 1, co-authored 2 publications receiving 5 citations.

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Journal ArticleDOI
TL;DR: Insight is provided on recent research on the health properties of plant Sambucus nigra as an antiviral medication that may help propose new therapy.
Abstract: Nowadays, the application of alternative methods instead of clinical treatment creates a new possibility to prevent the development of diseases Medicinal plants such as Sambucus nigra have been well known due to their extraordinary properties The similarity to synthetic substances makes it potentially dependable;however, a high concentration of cyanogenic glycosides may exert detrimental consequences It has been documented that Sambucus nigra extracts are used against both human and animal viruses, like influenza A and B viruses, human immunodeficiency virus (HIV), dengue virus (DENV-2), human herpesvirus type 1 (HSV-1) and human coronavirus NL63 (HCoV-NL63) Such reports are notably valuable especially considering the widespread usage of commercial drugs, which could be ineffective This review provides insight on recent research on the health properties of plant Sambucus nigra as an antiviral medication that may help propose new therapy © 2020 Centro de Biotecnologia y Biomedicina, Clinical Biotec Universidad CatA³lica del Oriente (UCO), Univesidad Yachay Tech All right reserved

18 citations

Journal ArticleDOI
04 Oct 2021-Viruses
TL;DR: Sialodacryoadenitis virus (SDAV) is known to be an etiological agent, causing infections in laboratory rats as mentioned in this paper, but its role has only been considered in studies on respiratory and salivary gland infections.
Abstract: Sialodacryoadenitis virus (SDAV) is known to be an etiological agent, causing infections in laboratory rats. Until now, its role has only been considered in studies on respiratory and salivary gland infections. The scant literature data, consisting mainly of papers from the last century, do not sufficiently address the topic of SDAV infections. The ongoing pandemic has demonstrated, once again, the role of the Coronaviridae family as extremely dangerous etiological agents of human zoonoses. The ability of coronaviruses to cross the species barrier and change to hosts commonly found in close proximity to humans highlights the need to characterize SDAV infections. The main host of the infection is the rat, as mentioned above. Rats inhabit large urban agglomerations, carrying a vast epidemic threat. Of the 2277 existing rodent species, 217 are reservoirs for 66 zoonotic diseases caused by viruses, bacteria, fungi, and protozoa. This review provides insight into the current state of knowledge of SDAV characteristics and its likely zoonotic potential.

2 citations

Journal ArticleDOI
TL;DR: It is demonstrated, for the first time, that EHV-1 infection leads to inhibition of proliferation and migration in A172 cells, which might be promising for new immunotherapy treatment.
Abstract: Equid alphaherpesvirus 1 (EHV-1) causes respiratory diseases, abortion, and neurological disorders in horses. Recently, the oncolytic potential of this virus and its possible use in anticancer therapy has been reported, but its influence on cytoskeleton was not evaluated yet. In the following study, we have examined disruptions in actin cytoskeleton of glioblastoma multiforme in vitro model—A172 cell line, caused by EHV-1 infection. We used three EHV-1 strains: two non-neuropathogenic (Jan-E and Rac-H) and one neuropathogenic (EHV-1 26). Immunofluorescent labelling, confocal microscopy, real-time cell growth analysis and OrisTM cell migration assay revealed disturbed migration of A172 cells infected with the EHV-1, probably due to rearrangement of actin cytoskeleton and the absence of cell projections. All tested strains caused disruption of the actin network and general depolymerization of microfilaments. The qPCR results confirmed the effective replication of EHV-1. Thus, we have demonstrated, for the first time, that EHV-1 infection leads to inhibition of proliferation and migration in A172 cells, which might be promising for new immunotherapy treatment.

1 citations


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DOI
01 Jan 2020

1,967 citations

Journal ArticleDOI
TL;DR: Investigation of the immunomodulative and antiviral effects of a high-quality, anthocyanin-enriched elderberry fruit extract reveals that elderberry extract reduced the secretion of pro-inflammatory cytokines TNF-α and IFN-γ, leading to a shift towards the Th2-Helper cell response and showing antiviral efficacy against the MVA virus.
Abstract: Infections of the respiratory system, including common cold and influenza, are affecting people worldwide and are more or less prone to spread depending on the season and viral load of the host. Fo...

14 citations

Journal ArticleDOI
TL;DR: A comprehensive overview of dengue virus infections, clinical symptoms, diagnosis, mitigation, and treatments, focusing on ayurvedic and herbal remedies, is provided in this article , where Carica papaya, Cissampelos pareira, etc.
Abstract: Dengue fever is a flu-like ailment propagated by female mosquitos of the Aedes aegypti species. It is also known as dandaka jwara in Ayurveda. It is most common in the world's subtropical and tropical climate zones. Vomiting, severe headache, nausea, rashes, joint pain, pain behind the eyes, muscle pain, and swollen glands are all common dengue symptoms. If not handled promptly, these symptoms can lead to more severe issues such as exhaustion, blood in the vomit, continuous vomiting, bleeding gums, restlessness, severe abdominal pain, and rapid bleeding. Because there is no specific medication for dengue fever, the disease is treated by eliminating and managing the symptoms. Fortunately, there are a variety of ayurvedic remedies (like Carica papaya L., Cissampelos pareira L., etc. ) that can help to tackle the same by strengthening the immune system and controlling hyperthermia. This review article provides a comprehensive overview of dengue virus infections, clinical symptoms, diagnosis, mitigation, and treatments, focusing on ayurvedic and herbal remedies.

9 citations

Journal ArticleDOI
TL;DR: In this article , the authors provided information on the ethnobotanical uses, phytochemistry, toxicity, and known biological properties of Sambucus, to understand their connotations and provide a scientific basis and gaps for further research.

8 citations

Journal ArticleDOI
05 Nov 2021-Foods
TL;DR: In this article, the main bioactive compounds present in elderberries, as well as their potential uses in the food industry, are reviewed, and a strategy for adding elderberry to food should be studied to ensure a positive effect on nutritional and technological properties without affecting (or improving) the sensory quality of foods.
Abstract: The food industry, in response to current consumer demand for natural and functional foods, is constantly evolving and reformulating traditional products formulations. Thus, during the last decades, multiple natural sources have been investigated to replace the need to add synthetic additives. In addition, the use of natural sources can also increase the nutritional quality of the food. With this in mind, elderberry is used in the food industry for certain purposes. However, its potential is much higher than the number of applications it currently has. Its high content of anthocyanins, as well as other polyphenols and vitamins, means that it can be used by the food industry both as a colorant and as an antioxidant. In addition, the incorporation of these bioactive compounds results in functional foods, with a high antioxidant capacity. Moreover, the inclusion of elderberry products in foods formulation increases their shelf-life, but the correct amount and strategy for adding elderberry to food should be studied to ensure a positive effect on nutritional and technological properties without affecting (or improving) the sensory quality of foods. Therefore, this manuscript aims to review the main bioactive compounds present in elderberries, as well as their potential uses in the food industry.

8 citations