M
Michel Koole
Researcher at Katholieke Universiteit Leuven
Publications - 222
Citations - 6305
Michel Koole is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 34, co-authored 193 publications receiving 5122 citations. Previous affiliations of Michel Koole include Ghent University & University Medical Center Groningen.
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Journal ArticleDOI
GATE : a simulation toolkit for PET and SPECT
Sébastien Jan,Giovanni Santin,D. Strul,D. Strul,Steven Staelens,Karine Assié,D. Autret,Stéphane Avner,Remi Barbier,Manuel Bardiès,Peter M. Bloomfield,David Brasse,Vincent Breton,P. Bruyndonckx,Irène Buvat,Arion F. Chatziioannou,Yong Choi,Y. H. Chung,Claude Comtat,D. Donnarieix,Ludovic Ferrer,Stephen J. Glick,C. J. Groiselle,David Guez,P. F. Honore,S. Kerhoas-Cavata,Assen S. Kirov,V. Kohli,Michel Koole,M. Krieguer,D.J. van der Laan,F. Lamare,G. Largeron,Carole Lartizien,D. Lazaro,Marnix C. Maas,Lydia Maigne,F. Mayet,F. Melot,C. Merheb,E. Pennacchio,J. Perez,Uwe Pietrzyk,F. R. Rannou,F. R. Rannou,M. Rey,Dennis R. Schaart,Charles Schmidtlein,Luc Simon,Luc Simon,Tae Yong Song,J. M. Vieira,Dimitris Visvikis,R. T. Van de Walle,E. Wieers,Christian Morel +55 more
TL;DR: A detailed description of the design and development of GATE is given by the OpenGATE collaboration, whose continuing objective is to improve, document and validate GATE by simulating commercially available imaging systems for PET and SPECT.
Journal ArticleDOI
Phase 1 Study of the Pittsburgh Compound B Derivative 18F-Flutemetamol in Healthy Volunteers and Patients with Probable Alzheimer Disease
Natalie Nelissen,Koen Van Laere,Lennart Thurfjell,Rikard Owenius,Mathieu Vandenbulcke,Michel Koole,Guy Bormans,David J. Brooks,Rik Vandenberghe +8 more
TL;DR: 18F-flutemetamol uptake can be readily quantified and warrants further studies to validate this 18F-labeled derivative of PiB as a biomarker for Aβ amyloidosis.
Journal ArticleDOI
Whole-Body Biodistribution and Radiation Dosimetry of 18F-GE067: A Radioligand for In Vivo Brain Amyloid Imaging
Michel Koole,Dewi M. Lewis,Christopher Buckley,Natalie Nelissen,Mathieu Vandenbulcke,David J. Brooks,Rik Vandenberghe,Koen Van Laere +7 more
TL;DR: The estimated effective dose of 18F-GE067 for PET amyloid imaging was acceptable (class II-b defined by the World Health Organization), and relatively low variability between subjects was observed.
Journal ArticleDOI
Iterative reconstruction algorithms in nuclear medicine.
Stefaan Vandenberghe,Yves D'Asseler,R. Van de Walle,Tomi Kauppinen,Michel Koole,L. Bouwens,K. Van Laere,Ignace Lemahieu,Rudi Dierckx +8 more
TL;DR: An overview of the most important iterative techniques and discuss the different corrections that can be incorporated to improve the image quality are given.
Journal ArticleDOI
99mTc-ECD brain perfusion SPET: variability, asymmetry and effects of age and gender in healthy adults.
Koenraad Van Laere,Jan Versijpt,Kurt Audenaert,Michel Koole,Ingeborg Goethals,E Achten,Rudi Dierckx +6 more
TL;DR: A large dataset of normal technetium-99m labelled ethylene cysteine dimer perfusion SPET in carefully screened healthy volunteers with an age range spanning six decades was created, with correction for non-uniform attenuation and scatter and based on an anatomically standardised analysis.