Michel Rabinovitch

TL;DR: In the Metazoa, phagocytosis underlies the uptake and degradation of microorganisms, damaged or senescent cells, and particulates such as pollutants, by specialized phago- cytic cells and is related to pino- cytosis, the process responsible for the cellular uptake of fluid, solutes, col- loids, macromolecules, virusesorsmall particles, and for bulk internalization of the plasma membrane.

TL;DR: Evidence was obtained that C3 is primarily involved in particle attachment, whereas only IgG is able to markedly promote the ingestion of particles attached to macrophages and the possible relevance of these findings for the in vivo fate of particulate immune complexes as they interact with macrophage monolayers is discussed.

TL;DR: The results suggest that transit through the autophagic pathway increases the infection with Coxiella by providing a niche more favourable to their initial survival and multiplication.

TL;DR: It is proposed that C.’burnetii transits through the normal endo/phagocytic pathway but actively interacts with autophagosomes at early times after infection, possibly favouring the intracellular differentiation and survival of the bacteria.

TL;DR: Results suggest that Rab7 participates in the biogenesis of the parasitophorous vacuoles in Coxiella burnetii, and suggest that the agent of Q fever in humans and of coxiellosis in other animals interacts with the autophagic pathway.