M
Michelangelo Cordenonsi
Researcher at University of Padua
Publications - 57
Citations - 18961
Michelangelo Cordenonsi is an academic researcher from University of Padua. The author has contributed to research in topics: Hippo signaling pathway & Biology. The author has an hindex of 37, co-authored 51 publications receiving 15487 citations.
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Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
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YAP/TAZ at the Roots of Cancer
TL;DR: In this paper, a number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling, and regulation of the Hippo pathway.
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The Biology of YAP/TAZ: Hippo Signaling and Beyond
TL;DR: YAP/TAZ appear at the centerpiece of a signaling nexus by which cells take control of their behavior according to their own shape, spatial location and growth factor context, and are appealing therapeutic targets in cancer and regenerative medicine.
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The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
Michelangelo Cordenonsi,Francesca Zanconato,Luca Azzolin,Mattia Forcato,Antonio Rosato,Chiara Frasson,Masafumi Inui,Marco Montagner,Anna Parenti,Alessandro Poletti,Maria Grazia Daidone,Sirio Dupont,Giuseppe Basso,Silvio Bicciato,Stefano Piccolo +14 more
TL;DR: It is shown that the activity of TAZ, a transducer of the Hippo pathway, is required to sustain self-renewal and tumor-initiation capacities in breast CSCs and reveals a mechanistic basis of the control of Hippo kinases by cell polarity.
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YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
Luca Azzolin,Tito Panciera,Sandra Soligo,Elena Enzo,Silvio Bicciato,Sirio Dupont,Silvia Bresolin,Chiara Frasson,Giuseppe Basso,Vincenza Guzzardo,Ambrogio Fassina,Michelangelo Cordenonsi,Stefano Piccolo +12 more
TL;DR: Evidence is provided that YAP and TAZ are integral components of the β-catenin destruction complex that serves as cytoplasmic sink for YAP/TAZ, revealing an unprecedented signaling framework relevant for organ size control, regeneration, and tumor suppression.