M
Michele Bombardieri
Researcher at Queen Mary University of London
Publications - 228
Citations - 9507
Michele Bombardieri is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Rheumatoid arthritis & Medicine. The author has an hindex of 48, co-authored 201 publications receiving 7260 citations. Previous affiliations of Michele Bombardieri include King's College London & University of London.
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Journal ArticleDOI
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
TL;DR: Investigations in both experimental model systems and patient cohorts are discussed to provide a perspective on the formation and functions of ectopic lymphoid-like structures in human pathology, with particular reference to the clinical implications and the potential for therapeutic targeting.
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Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Frances Humby,Michele Bombardieri,Antonio Manzo,Stephen Kelly,Mark Blades,Bruce Kirkham,Jo Spencer,Costantino Pitzalis +7 more
TL;DR: It is demonstrated that FDC+ follicular units invariably express AID and are surrounded by ACPA-producing plasma cells, providing strong evidence that ectopic lymphoid structures in the RA synovium are functional and support autoantibody production.
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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.
Robert Haas,Joanne Smith,Vidalba Rocher-Ros,Suchita Nadkarni,Trinidad Montero-Melendez,Fulvio D'Acquisto,Elliot James Bland,Michele Bombardieri,Costantino Pitzalis,Mauro Perretti,Federica M. Marelli-Berg,Claudio Mauro +11 more
TL;DR: A novel role of lactate is established in control of proinflammatory T cell motility and effector functions, which provides a potential molecular mechanism for T cell entrapment and functional changes in inflammatory sites that drive chronic inflammation and offer targeted therapeutic interventions for the treatment of chronic inflammatory disorders.
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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.
Valentina Pucino,Valentina Pucino,Michelangelo Certo,Michelangelo Certo,Vinay Bulusu,Danilo Cucchi,Katriona Goldmann,Elena Pontarini,Robert Haas,Joanne Smith,Sarah E. Headland,K. Blighe,Massimiliano Ruscica,Frances Humby,Myles Lewis,Jurre J. Kamphorst,Michele Bombardieri,Costantino Pitzalis,Claudio Mauro +18 more
TL;DR: It is proposed that lactate/SLC5A12-induced metabolic reprogramming is a distinctive feature of lymphoid synovitis in rheumatoid arthritis patients and a potential therapeutic target in chronic inflammatory disorders.
Journal ArticleDOI
Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome
Francesca Barone,Michele Bombardieri,Antonio Manzo,Mark Blades,Peter Morgan,Stephen Challacombe,Guido Valesini,Costantino Pitzalis +7 more
TL;DR: The acquisition of lymphoid features byinflammatory foci in SS is critically associated with the enlargement of the inflammatory foci and with the expression of CXCL13 and CCL21 within the infiltrate, but is not associated with their expression by epithelial cells.