Michele Weber

TL;DR: These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues.

TL;DR: It is shown that chemotactic dendritic cells mechanically adapt to the adhesive properties of their substrate by switching between integrin-mediated andIntegrin-independent locomotion, which endowed these 'amoeboid' cells with extraordinary flexibility, enabling them to traverse almost every type of tissue.

TL;DR: This study generated pure populations of immature human LCs in vitro to systematically probe for gene‐expression changes during LC maturation and suggests that N‐cadherin plays a role during DC migration.

TL;DR: It is shown that podoplanin is also expressed byThymic fibroblastic reticular cells (tFRC), a novel thymic medulla stroma cell type associated with thymo- conduits, and involved in development of natural regulatory T cells (nTreg) and in death-causing autoimmune phenotype of Foxp3-deficient Scurfy mice.

TL;DR: An ex vivo crawl-in assay using explanted mouse ears that allows the visualization of chemokine-dependent dendritic cell motility in the dermal interstitium in real time and provides a more physiological approach to study leukocyte migration than in vitro three-dimensional or 2-dimensional migration assays such as collagen gels and transwell assays.