Michelle A. Anderson

TL;DR: It is shown that Tregs are a key source of TGFβ ligands and, accordingly, their depletion reprogramed the fibroblast population, with loss of tumor-restraining, smooth muscle actin-expressing fibroblasts (myCAFs), and supports the notion that fibro Blasts are a heterogeneous population with different and opposing functions in pancreatic carcinogenesis.

TL;DR: Tumor-infiltrating CD8+ T cells had an increased proportion of cells expressing an exhausted expression profile that included upregulation of the immune checkpoint TIGIT, a finding that was validated at the protein level.

TL;DR: This guideline is intended to be an educational device o provide information that may assist endoscopists in roviding care to patients that is based on both the aggregate evidence quality and an assessment of the anticipated benefits and harms.

TL;DR: In this paper, the authors recommend that endoscopic findings of reflux esophagitis be classified according to an accepted grading scale or described in detail, without the use of diagnostic testing, including EGD.

TL;DR: WNK1-SPAK pathway-activated increases in CFTR bicarbonate permeability are altered by CFTRBD variants through multiple mechanisms, and molecular dynamics simulations suggest physical restriction of the CFTR channel and altered dynamic channel regulation.