Michelle D. Tadmor

TL;DR: Using hematopoietic progenitors, a signaling-based measure of cellular phenotype was defined, which led to isolation of a gene expression signature that was predictive of survival in independent cohorts, yielding insights into AML pathophysiology.

TL;DR: In this article, the authors present viSNE, a tool that allows one to map high-dimensional cytometry data onto two dimensions, yet conserve the highdimensional structure of the data by using all pairwise distances in high dimension to determine each cell's location in the plot.

TL;DR: This study provides a comprehensive analysis of human B lymphopoiesis, laying a foundation to apply this approach to other tissues and "corrupted" developmental processes including cancer.

TL;DR: Wishbone, an algorithm for positioning single cells along bifurcating developmental trajectories with high resolution, is presented and it is shown that it outperforms diffusion maps, SCUBA and Monocle both in the accuracy of ordering cells and in the correct identification of branch points.

TL;DR: Cycler is presented, a robust method that constructs a continuous trajectory of cell-cycle progression from images of fixed cells that handles heterogeneous microenvironments and does not require perturbations or genetic markers, making it generally applicable to quantifying multiple sources ofcell-to-cell variability in mammalian cells.