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Michelle L. Kienholz
Researcher at University of Pittsburgh
Publications - 4
Citations - 617
Michelle L. Kienholz is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Randomized controlled trial & Genome-wide association study. The author has an hindex of 4, co-authored 4 publications receiving 525 citations.
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Journal ArticleDOI
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
David C. Whitcomb,Jessica LaRusch,Alyssa M. Krasinskas,Lambertus Klei,Jill P. Smith,Randall E. Brand,John P. Neoptolemos,Markus M. Lerch,Matt Tector,Bimaljit S. Sandhu,Nalini M. Guda,Lidiya Orlichenko,Samer Alkaade,Stephen T. Amann,Michelle A. Anderson,John Baillie,Peter A. Banks,Darwin L. Conwell,Gregory A. Cote,Peter B. Cotton,James A. DiSario,Lindsay A. Farrer,Chris E. Forsmark,Marianne Johnstone,Timothy B. Gardner,Andres Gelrud,William Greenhalf,Jonathan L. Haines,Douglas J. Hartman,Robert A. Hawes,Christopher Lawrence,Michele D. Lewis,Julia Mayerle,Richard Mayeux,Nadine M. Melhem,Mary E. Money,Thiruvengadam Muniraj,Georgios I. Papachristou,Margaret A. Pericak-Vance,Joseph Romagnuolo,Gerard D. Schellenberg,Stuart Sherman,Peter Simon,Vijay P. Singh,Adam Slivka,Donna B. Stolz,Robert Sutton,Frank Ulrich Weiss,C. Mel Wilcox,Narcis O. Zarnescu,Stephen R. Wisniewski,Michael R. O'Connell,Michelle L. Kienholz,Kathryn Roeder,M. Michael Barmada,Dhiraj Yadav,Bernie Devlin,Marilyn S. Albert,Roger L. Albin,Roger L. Albin,Liana G. Apostolova,Steven E. Arnold,Clinton T. Baldwin,Robert Barber,Lisa L. Barnes,Thomas G. Beach,Gary W. Beecham,Duane Beekly,David A. Bennett,Eileen H. Bigio,Thomas D. Bird,Deborah Blacker,Adam L. Boxer,James R. Burke,Joseph D. Buxbaum,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Regina M. Carney,Steven L. Carroll,Helena C. Chui,David G. Clark,David H. Cribbs,Elizabeth Crocco,Carlos Cruchaga,Charles DeCarli,F. Yesim Demirci,Malcolm B. Dick,Dennis W. Dickson,Ranjan Duara,Nilufer Ertekin-Taner,Kelley Faber,Kenneth B. Fallon,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Matthew P. Frosch,Douglas Galasko,Mary Ganguli,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Sid Gilman,Jonathan D. Glass,Alison Goate,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Hakon Hakonarson,Kara L. Hamilton-Nelson,Ronald L. Hamilton,Lindy E. Harrell,Elizabeth Head,Lawrence S. Honig,Christine M. Hulette,Bradley T. Hyman,Gregory A. Jicha,Lee-Way Jin,Gyungah Jun,M. Ilyas Kamboh,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Edward H. Koo,Neil W. Kowall,Joel H. Kramer,Patricia L. Kramer,Walter A. Kukul,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Chiao-Feng Lin,Andrew P. Lieberman,Oscar L. Lopez,Kathryn L. Lunetta,Constantine G. Lyketsos,Wendy J. Mack,Daniel C. Marson,Eden R. Martin,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Thomas J. Montine,John C. Morris,Jill R. Murrel,Adam C. Naj,Adam C. Naj,John M Olichney,Joseph E. Parisi,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Eric M. Reiman,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Howard J. Rosen,Roger N. Rosenberg,Mary Sano,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Rudolph E. Tanzi,John Q. Trojanowski,Juan C. Troncoso,Juan C. Troncoso,Debby W. Tsuang,Otto Valladares,Vivianna M. Van Deerlin,Linda J. Van Eldik,Badri N. Vardarajan,Harry V. Vinters,Jean Paul Vonsatte,Li-San Wang,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Jennifer Williamson,Randall L. Woltjer,Clinton B. Wright,Steven G. Younkin,Chang En Yu,Lei Yu +201 more
TL;DR: Two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 are reported and could partially explain the high frequency of alcohol-related pancreatitis in men.
Journal ArticleDOI
Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.
Jessica LaRusch,Jinsei Jung,Ignacio J. General,Michele D. Lewis,Hyun Woo Park,Randall E. Brand,Andres Gelrud,Michelle A. Anderson,Peter A. Banks,Darwin L. Conwell,Christopher Lawrence,Joseph Romagnuolo,John Baillie,Samer Alkaade,Gregory A. Cote,Timothy B. Gardner,Stephen T. Amann,Adam Slivka,Bimaljit S. Sandhu,Amy Aloe,Michelle L. Kienholz,Dhiraj Yadav,M. Michael Barmada,Ivet Bahar,Min Goo Lee,David C. Whitcomb +25 more
TL;DR: WNK1-SPAK pathway-activated increases in CFTR bicarbonate permeability are altered by CFTRBD variants through multiple mechanisms, and molecular dynamics simulations suggest physical restriction of the CFTR channel and altered dynamic channel regulation.
Journal ArticleDOI
Factors That Influence Parental Decisions to Participate in Clinical Research: Consenters vs Nonconsenters
Alejandro Hoberman,Nader Shaikh,Sonika Bhatnagar,Mary Ann Haralam,Diana H. Kearney,D. Kathleen Colborn,Michelle L. Kienholz,Li Wang,Clareann H. Bunker,Ron Keren,Myra A. Carpenter,Saul P. Greenfield,Hans G. Pohl,Ranjiv Mathews,Marva Moxey-Mims,Russell W. Chesney +15 more
TL;DR: Parents who declined consent had a relatively higher socioeconomic status, had more anxiety about their decision, and found it harder to make their decision compared with consenting parents, who had higher levels of trust and altruism, perceived the potential for enhanced care, reflected better understanding of randomization, and exhibited low decisional uncertainty.
Factors That Influence Parental Decisions to Participate in Clinical Research
Alejandro Hoberman,Nader Shaikh,Sonika Bhatnagar,Mary Ann Haralam,Diana H. Kearney,D. Kathleen Colborn,Michelle L. Kienholz,Li Wang,Clareann H. Bunker,Ron Keren,Myra A. Carpenter,Saul P. Greenfield,Hans G. Pohl,Ranjiv Mathews,Marva Moxey-Mims,Russell W. Chesney +15 more
TL;DR: In this paper, a 60-question survey examining child, parent, and study characteristics was conducted to examine factors influencing their decision to participate in a randomized trial with a child participant.