M
Michelle Letarte
Researcher at University of Toronto
Publications - 145
Citations - 10322
Michelle Letarte is an academic researcher from University of Toronto. The author has contributed to research in topics: Endoglin & Antigen. The author has an hindex of 51, co-authored 145 publications receiving 9818 citations. Previous affiliations of Michelle Letarte include Hospital for Sick Children & University of Turin.
Papers
More filters
Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Journal ArticleDOI
Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily
TL;DR: The data suggest that endoglin is an accessory protein of multiple kinase receptor complexes of the TGF-β superfamily.
Journal ArticleDOI
A murine model of hereditary hemorrhagic telangiectasia.
TL;DR: It is suggested that endoglin is critical for both angiogenesis and heart valve formation and epigenetic factors and modifier genes, some of which are present in 129/Ola, contribute to disease heterogeneity.
Journal Article
Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy.
Francis Burrows,Elaine J. Derbyshire,Pier Luigi Tazzari,Peter Amlot,Adi F. Gazdar,Adi F. Gazdar,Steven W. King,Steven W. King,Michelle Letarte,Ellen S. Vitetta,Philip E. Thorpe +10 more
TL;DR: The increased binding of TEC-11 to tumor vasculature and to dividing as opposed to noncycling HUVECs in vitro suggests that endoglin is an endothelial cell proliferation-associated marker, which might have therapeutic value in the treatment of solid tumors in humans.
Journal ArticleDOI
Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease
Salma A Abdalla,Michelle Letarte +1 more
TL;DR: Current knowledge on the genetics of HHT is summarised, including the pathways that link the genes responsible for HHT and the potential mechanisms underlying the pathogenesis of the disease.