M
Michelle M. McDonald
Researcher at Garvan Institute of Medical Research
Publications - 86
Citations - 4544
Michelle M. McDonald is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Bone healing & Osteoclast. The author has an hindex of 26, co-authored 79 publications receiving 3659 citations. Previous affiliations of Michelle M. McDonald include Children's Hospital at Westmead & Boston Children's Hospital.
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Journal ArticleDOI
Bone remodeling during fracture repair : The cellular picture
TL;DR: This review has attempted to examine catabolism/remodeling in fractures in a systematic fashion by examining the cellular participants in soft callus remodeling and in particular the role of the osteoclast in endochondral ossification.
Journal ArticleDOI
Bone metastasis: the importance of the neighbourhood
Peter I. Croucher,Peter I. Croucher,Michelle M. McDonald,Michelle M. McDonald,T. John Martin,T. John Martin +5 more
TL;DR: The role of different bone cell types in supporting disseminated tumour cell dormancy and reactivation is discussed, and the new opportunities this provides for targeting the bone microenvironment to control dormancies and bone metastasis are highlighted.
Journal ArticleDOI
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.
Michelle A. Lawson,Michelle M. McDonald,Michelle M. McDonald,Nataša Kovačić,Weng Hua Khoo,Weng Hua Khoo,Rachael L. Terry,Rachael L. Terry,Jenny Down,Warren Kaplan,Warren Kaplan,Julia Paton-Hough,Clair Fellows,Jessica A. Pettitt,T. Neil Dear,Els Van Valckenborgh,Paul A. Baldock,Paul A. Baldock,Michael J. Rogers,Michael J. Rogers,Colby L. Eaton,Karin Vanderkerken,Allison R. Pettit,Julian M.W. Quinn,Andrew C.W. Zannettino,Tri Giang Phan,Tri Giang Phan,Peter I. Croucher,Peter I. Croucher +28 more
TL;DR: It is demonstrated that dormancy is a reversible state that is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched ‘off' by osteoclasts remodelling the endosteal niche.
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The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering.
Hala Zreiqat,Yogambha Ramaswamy,Chengtie Wu,Angelo Paschalidis,Zufu Lu,B. W. James,Oliver Birke,Michelle M. McDonald,David G. Little,Colin R. Dunstan +9 more
TL;DR: In vivo, HT and Sr-HT produced distinct differences in the patterns of degradation of the materials, and their association with TRAP positive osteoclast-like cells with HT appearing more resistant compared to both Sr- HT and beta-TCP.
Journal ArticleDOI
Optimal Timing of a Single Dose of Zoledronic Acid to Increase Strength in Rat Fracture Repair
Negin Amanat,Negin Amanat,Michelle M. McDonald,Craig Godfrey,Lynne E. Bilston,David G. Little,David G. Little +6 more
TL;DR: In a rat model for closed fracture healing, a single dose of ZA at 0, 1, or 2 wk after fracture significantly increased BMC and strength of the healed fracture.