M
Michikazu Abe
Researcher at University of Virginia
Publications - 6
Citations - 2733
Michikazu Abe is an academic researcher from University of Virginia. The author has contributed to research in topics: Circadian rhythm & Light effects on circadian rhythm. The author has an hindex of 4, co-authored 6 publications receiving 2564 citations. Previous affiliations of Michikazu Abe include Northwestern University.
Papers
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Journal ArticleDOI
Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats
Shin Yamazaki,Rika Numano,Michikazu Abe,Akiko Hida,Ri Ichi Takahashi,Masatsugu Ueda,Gene D. Block,Yoshiyuki Sakaki,Michael Menaker,Hajime Tei +9 more
TL;DR: It is hypothesize that a self-sustained circadian pacemaker in the SCN entrains circadian oscillators in the periphery to maintain adaptive phase control, which is temporarily lost following large, abrupt shifts in the environmental light cycle.
Journal ArticleDOI
Circadian rhythms in isolated brain regions.
Michikazu Abe,Erik D. Herzog,Erik D. Herzog,Shin Yamazaki,Marty Straume,Hajime Tei,Yoshiyuki Sakaki,Michael Menaker,Gene D. Block +8 more
TL;DR: The results indicate that the brain contains multiple, damped circadian oscillators outside the SCN, and the phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle.
Journal ArticleDOI
Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons.
TL;DR: Results indicate that lithium acts directly on the mammalian suprachiasmatic nucleus (SCN) to lengthen the free-running period of individual neurons.
Journal ArticleDOI
Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice in vivo
Lisa D. Wilsbacher,Shin Yamazaki,Erik D. Herzog,Eun Joo Song,Laurel A. Radcliffe,Michikazu Abe,Gene D. Block,Edward L. Spitznagel,Michael Menaker,Joseph S. Takahashi +9 more
TL;DR: This approach demonstrates that the 6.75-kb mPer1 promoter fragment is sufficient to confer both circadian and photic regulation in vivo and reveals a potential posttranscriptional regulatory mechanism within the mammalian circadian oscillator.
Patent
Transgenic mammals introduced a Period 1 promoter that confers rhythmical expression
TL;DR: In this paper, an isolated Period 1 (Per1) promoter DNA inducing rhythmical expression of a gene operably linked to the promoter DNA was presented, which is useful in the screening of pharmaceutical drugs against diseases and disorders pertaining to the circadian rhythm.