M
Michinari Nakamura
Researcher at Rutgers University
Publications - 17
Citations - 1530
Michinari Nakamura is an academic researcher from Rutgers University. The author has contributed to research in topics: Diabetic cardiomyopathy & Medicine. The author has an hindex of 9, co-authored 13 publications receiving 766 citations.
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Journal ArticleDOI
Mechanisms of physiological and pathological cardiac hypertrophy
TL;DR: The characteristics and underlying mechanisms of physiological and pathological hypertrophy are summarized, and possible therapeutic strategies targeting these pathways to prevent or reverse pathological hyperTrophy are discussed.
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Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy.
Mingming Tong,Toshiro Saito,Peiyong Zhai,Shin Ichi Oka,Wataru Mizushima,Michinari Nakamura,Shohei Ikeda,Akihiro Shirakabe,Junichi Sadoshima +8 more
TL;DR: Mitophagy serves as an essential quality control mechanism for mitochondria in the heart during HFD consumption and protects against HFD-induced diabetic cardiomyopathy, as well as inducing systolic dysfunction and lipid accumulation in wild-type mice.
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Cardiomyopathy in obesity, insulin resistance and diabetes.
TL;DR: The molecular mechanisms of diabetic cardiomyopathy are summarized, with a special emphasis on cardiac lipotoxicity, and the role of peroxisome proliferator‐activated receptor α and dysregulated fatty acid metabolism as potential therapeutic targets are discussed.
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Overview of pyridine nucleotides review series.
TL;DR: It has recently been demonstrated that pyridine nucleotides and the balance between the oxidized and reduced forms play a wide variety of pivotal roles in cellular functions as important interfaces, beyond their coenzymatic activity.
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Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy.
Michinari Nakamura,Tong Liu,Seema Husain,Peiyong Zhai,Junco S. Warren,Chiao-Po Hsu,Takahisa Matsuda,Christopher J. Phiel,James E. Cox,Bin Tian,Hong Li,Junichi Sadoshima +11 more
TL;DR: It is suggested that GSK-3α promotes lipid anabolism through PPARα-Ser280 phosphorylation, which underlies the development of lipotoxic cardiomyopathy in the context of obesity.