M
Michiru Nishita
Researcher at Kobe University
Publications - 52
Citations - 17539
Michiru Nishita is an academic researcher from Kobe University. The author has contributed to research in topics: Receptor tyrosine kinase & Wnt signaling pathway. The author has an hindex of 29, co-authored 50 publications receiving 12478 citations. Previous affiliations of Michiru Nishita include Fukushima Medical University & Tohoku University.
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Journal ArticleDOI
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Michiru Nishita,Seung-Yeol Park,Tadashi Nishio,Koki Kamizaki,ZhiChao Wang,Kota Tamada,Toru Takumi,Ryuju Hashimoto,Hiroki Otani,Gregory J. Pazour,Victor W. Hsu,Yasuhiro Minami +11 more
TL;DR: It is found that intraflagellar transport 20 mediates the ability of Ror2 signaling to induce the invasiveness of tumors that lack primary cilia, and IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex.
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Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis
Kazuhiro Maeda,Yasuhiro Kobayashi,Nobuyuki Udagawa,Shunsuke Uehara,Akihiro Ishihara,Toshihide Mizoguchi,Yuichiro Kikuchi,Ichiro Takada,Shigeaki Kato,Shuichi Kani,Michiru Nishita,Keishi Marumo,T. John Martin,Yasuhiro Minami,Naoyuki Takahashi +14 more
TL;DR: The results suggest that the Wnt5a-Ror2 pathway is crucial for osteoclastogenesis in physiological and pathological environments and represents a therapeutic target for bone diseases, including arthritis.
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Cthrc1 Selectively Activates the Planar Cell Polarity Pathway of Wnt Signaling by Stabilizing the Wnt-Receptor Complex
Shinji Yamamoto,Osamu Nishimura,Kazuyo Misaki,Michiru Nishita,Yasuhiro Minami,Shigenobu Yonemura,Hiroshi Tarui,Hiroshi Sasaki +7 more
TL;DR: Results suggest that Cthrc1 is a Wnt cofactor protein that selectively activates the Wnt/PCP pathway by stabilizing ligand-receptor interaction.
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Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
TL;DR: Recent progress in understanding the roles of noncanonical Wnt5a/Ror2 signaling in developmental morphogenesis and in human diseases, including heritable skeletal disorders and tumor invasion is reviewed.
Journal ArticleDOI
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.
Fenglei He,Wei Xiong,Wei Xiong,Xueyan Yu,Ramón A. Espinoza-Lewis,Ramón A. Espinoza-Lewis,Chao Liu,Chao Liu,Shuping Gu,Michiru Nishita,Kentaro Suzuki,Gen Yamada,Yasuhiro Minami,Yiping Chen,Yiping Chen +14 more
TL;DR: This work shows that Wnt5a and its receptor Ror2 are expressed in a graded manner along the AP axis of the palate, and reveals distinct regulatory roles for Wnt 5a in gene expression and cell proliferation and an essential role in the regulation of directional cell migration within the developing palate.