M
Mieczyslaw A. Piatyszek
Researcher at University of Texas Southwestern Medical Center
Publications - 27
Citations - 15459
Mieczyslaw A. Piatyszek is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 24, co-authored 27 publications receiving 15082 citations. Previous affiliations of Mieczyslaw A. Piatyszek include McMaster University & Hiroshima University.
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
Journal ArticleDOI
Telomerase activity in human germline and embryonic tissues and cells
TL;DR: Elucidation of the regulatory pathways involved in the repression of telomerase activity during development may lead to the ability to manipulate telomere levels and explore the consequences both for cellular aging and for the survival of cancer cells.
Journal Article
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
Keiko Hiyama,Y Hirai,Seishi Kyoizumi,M Akiyama,Eiso Hiyama,Mieczyslaw A. Piatyszek,Jerry W. Shay,Shinichi Ishioka,Michio Yamakido +8 more
TL;DR: It is demonstrated that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging.
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Correlating telomerase activity levels with human neuroblastoma outcomes
Eiso Hiyama,Keiko Hiyama,Takashi Yokoyama,Yuichiro Matsuura,Mieczyslaw A. Piatyszek,Jerry W. Shay +5 more
TL;DR: Telomerase expression may be required as a critical step in the multigenetic process of tumorigenesis, and two different pathways may exist for the development of neuroblastoma.
Journal ArticleDOI
Telomere Shortening Is Associated with Cell Division in Vitro and in Vivo
Richard C. Allsopp,Edwin Chang,Mohammad Kashefi-Aazam,Evgeny I. Rogaev,Mieczyslaw A. Piatyszek,Jerry W. Shay,Calvin B. Harley +6 more
TL;DR: Telomere shortening is largely, if not entirely, dependent on cell division and support the end replication problem as a mechanism for this process and the use of telomere length as a biomarker for replicative capacity.