M
Miguel A. de Pedro
Researcher at Spanish National Research Council
Publications - 78
Citations - 6856
Miguel A. de Pedro is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Peptidoglycan & Escherichia coli. The author has an hindex of 36, co-authored 78 publications receiving 5984 citations. Previous affiliations of Miguel A. de Pedro include Umeå University & University of North Dakota.
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Journal ArticleDOI
Peptidoglycan structure and architecture
TL;DR: In several species examined, the fine structure of the peptidoglycan significantly varies with the growth conditions, and the different models for the architecture are discussed with respect to structural and physical parameters.
Journal ArticleDOI
D-amino acids govern stationary phase cell wall remodeling in bacteria.
Hubert Lam,Dong-Chan Oh,Felipe Cava,Constantin N. Takacs,Jon Clardy,Miguel A. de Pedro,Matthew K. Waldor +6 more
TL;DR: It is found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures and appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall.
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In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D-Amino Acids†
Erkin Kuru,H. Velocity Hughes,Pamela J. B. Brown,Edward Hall,Srinivas Tekkam,Felipe Cava,Miguel A. de Pedro,Yves V. Brun,Michael S. VanNieuwenhze +8 more
TL;DR: Tracking a bug's life: Peptidoglycan (PG) of diverse bacteria is labeled by exploiting the tolerance of cells for incorporating different non-natural D-amino acids, thereby enabling fine spatiotemporal tracking of cell-wall dynamics in phylogenetically and morphologically diverse bacteria.
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Involvement of N-acetylmuramyl-L-alanine amidases in cell separation and antibiotic-induced autolysis of Escherichia coli.
Christoph Heidrich,Markus F. Templin,Astrid Ursinus,Melisa Merdanovic,Jürgen Berger,Heinz Schwarz,Miguel A. de Pedro,Joachim-Volker Höltje +7 more
TL;DR: It is reported that three amidases, named AmiA, B and C, exist in E. coli and that they are involved in splitting of the murein septum during cell division, and that the amidases were shown to act as powerful autolytic enzymes in the presence of antibiotics.
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Emerging knowledge of regulatory roles of d-amino acids in bacteria
TL;DR: Findings showing that d-amino acids have previously unappreciated regulatory roles in the bacterial kingdom are reviewed to reveal new paradigms for understanding how extracytoplasmic processes are regulated as well as lead to development of novel therapeutics.