Author
Mikihiro Inoue
Bio: Mikihiro Inoue is an academic researcher from Mie University. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 18, co-authored 126 publications receiving 985 citations.
Papers published on a yearly basis
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TL;DR: Cutting the incidence and severity of postsurgical adhesions with Seprafilm in pediatric patients may lead to reduction of the risks associated with subsequent operation.
54 citations
TL;DR: Synbiotics therapy may be very effective at improving the intestinal flora and systemic immunonutritional status of patients with SBS.
Abstract: The aim of this study was to evaluate the effects of synbiotic therapy in patients with short bowel syndrome (SBS). Four pediatric patients with SBS, who were receiving synbiotics therapy including Bifidobacterium breve, Lactobacillus casei and galactooligosaccharides, were enrolled in this study. We evaluated changes in immunonutritional parameters before and after receiving synbiotics therapy. Four normal, healthy, age-matched children were enrolled as controls. Fecal samples from patients and controls were collected and analyzed for fecal bacterial flora and organic acid (OA) contents. Levels of short chain fatty acids (SCFA) such as butyrate, propionate, and acetate increased in one patient, and SCFA/total OA levels increased in three patients. Serum lymphocyte counts and concentrations of pre-albumin increased after beginning synbiotics therapy, reaching a statistically significant level at the ninth month compared to the pre-treatment level. There was an increasing trend in height and weight gain velocity during the study compared with the pre-treatment period. The patients’ fecal bacterial flora improved as a result of synbiotics therapy. Synbiotics therapy may be very effective at improving the intestinal flora and systemic immunonutritional status of patients with SBS.
50 citations
TL;DR: Intraluminal appendiceal fluid is a predictive factor for recurrent appendicitis after initial non-operative management and may help to determine the appropriate management during the first episode of appendiciti.
46 citations
TL;DR: Remote ischemic conditioning, when administered in the early stages of disease progression, decreases intestinal injury and prolongs survival, and the mechanism of action involves increasing intestinal perfusion through vasodilation mediated by nitric oxide and hydrogen sulfide.
Abstract: Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal inflammation and ischemia, as well derangements in intestinal microcirculation. Remote ischemic conditioning (RIC) has emerged as a promising tool in protecting distant organs against ischemia-induced damage. However, the effectiveness of RIC against NEC is unknown. To address this gap, we aimed to determine the efficacy and mechanism of action of RIC in experimental NEC. NEC was induced in mouse pups between postnatal day (P) 5 and 9. RIC was applied through intermittent occlusion of hind limb blood flow. RIC, when administered in the early stages of disease progression, decreases intestinal injury and prolongs survival. The mechanism of action of RIC involves increasing intestinal perfusion through vasodilation mediated by nitric oxide and hydrogen sulfide. RIC is a viable and non-invasive treatment strategy for NEC.
39 citations
TL;DR: Glycolysis inhibitors are a potential therapeutic option for treating aggressive tumors expressing GLUT1 after in vitro studies showed that 3-Bromopyruvate acid significantly suppressed the proliferation of neuroblastoma cells with highGLUT1 gene expression compared with those with low expression.
39 citations
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TL;DR: The findings suggest that, although not the presenting feature, mild cognitive decline may be evident in the early stages of CJD associated with human cadaveric growth hormone treatment, and progression to dementia is best predicted by performance on neuropsychological tests.
1,194 citations
TL;DR: The study of the bacterial flora in anorexic patients revealed an increase in M. smithii, which might represent an adaptive use of nutrients in this population of patients linked to obesity in humans.
Abstract: Competing Interests: The « Universite de la Mediterranee » deposed a patent on this study for which the authors Armougom F., Henry M., Drancourt M., and Raoult D. are the inventors.
Funding: The authors have no support or funding to report.
776 citations
TL;DR: This guideline is intended to be flexible, not necessarily indicating the only acceptable approach, and should be distinguished from standards of care that are inflexible and rarely violated.
755 citations
Hebrew University of Jerusalem1, Hospital for Sick Children2, University of Miami3, Humanitas University4, Cincinnati Children's Hospital Medical Center5, University of California, San Diego6, Icahn School of Medicine at Mount Sinai7, Medical University of Vienna8, University of Amsterdam9, University of Paris10, University of Chicago11, University of Lorraine12, Rabin Medical Center13, Goethe University Frankfurt14
TL;DR: In a recent survey of 89 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD), a systematic review of the literature and iterative surveys of 89 IOIBD members, recommendations were drafted and modified in 2 surveys and 2 voting rounds as mentioned in this paper.
674 citations
TL;DR: The aim of the Consensus is to promote a European perspective on the management of ulcerative colitis (UC) and its dilemmas and to avoid duplication of effort in the future.
539 citations