M
Mikko Taipale
Researcher at University of Toronto
Publications - 74
Citations - 9807
Mikko Taipale is an academic researcher from University of Toronto. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 30, co-authored 58 publications receiving 8413 citations. Previous affiliations of Mikko Taipale include University of Helsinki & Massachusetts Institute of Technology.
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Journal ArticleDOI
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
TL;DR: Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.
Journal ArticleDOI
DNA-Binding Specificities of Human Transcription Factors
Arttu Jolma,Jian Yan,Tom Whitington,Jarkko Toivonen,Kazuhiro R. Nitta,Pasi Rastas,Ekaterina Morgunova,Martin Enge,Mikko Taipale,Gong-Hong Wei,Kimmo Palin,Juan M. Vaquerizas,Renaud Vincentelli,Nicholas M. Luscombe,Timothy P. Hughes,Patrick Lemaire,Esko Ukkonen,Teemu Kivioja,Teemu Kivioja,Jussi Taipale,Jussi Taipale +20 more
TL;DR: Global analysis of the data revealed that homodimer orientation and spacing preferences, and base-stacking interactions, have a larger role in TF-DNA binding than previously appreciated.
Journal ArticleDOI
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale,Irina Krykbaeva,Martina Koeva,Can Kayatekin,Kenneth D. Westover,Georgios I. Karras,Susan Lindquist,Susan Lindquist +7 more
TL;DR: In this paper, the authors systematically and quantitatively surveyed most human kinases, transcription factors, and E3 ligases for interaction with HSP90 and its cochaperone CDC37.
Journal ArticleDOI
Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo
Gong-Hong Wei,Gwenael Badis,Michael F. Berger,Teemu Kivioja,Teemu Kivioja,Kimmo Palin,Martin Enge,Martin Bonke,Arttu Jolma,Markku Varjosalo,Andrew R. Gehrke,Jian Yan,Shaheynoor Talukder,Mikko P. Turunen,Mikko Taipale,Hendrik G. Stunnenberg,Esko Ukkonen,Timothy P. Hughes,Martha L. Bulyk,Jussi Taipale,Jussi Taipale +20 more
TL;DR: The results indicate that even relatively small differences in in vitro binding specificity of a TF contribute to site selectivity in vivo, and this work identifies amino‐acid residues that are critical for the differences in specificity between all the classes.
Journal ArticleDOI
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni,Song Yi,Mikko Taipale,Juan I. Fuxman Bass,Jasmin Coulombe-Huntington,Fan Yang,Fan Yang,Jian Peng,Jochen Weile,Jochen Weile,Georgios I. Karras,Yang Wang,István Kovács,István Kovács,Atanas Kamburov,Irina Krykbaeva,Mandy H. Y. Lam,George Tucker,Vikram Khurana,Amitabh Sharma,Amitabh Sharma,Yang-Yu Liu,Yang-Yu Liu,Nozomu Yachie,Nozomu Yachie,Quan Zhong,Yun Shen,Alexandre Palagi,Adriana San-Miguel,Changyu Fan,Dawit Balcha,Amélie Dricot,Daniel M. Jordan,Jennifer M. Walsh,Akash A. Shah,Xinping Yang,Ani K. Stoyanova,Alex Leighton,Michael A. Calderwood,Yves Jacob,Yves Jacob,Michael E. Cusick,Kourosh Salehi-Ashtiani,Luke Whitesell,Shamil R. Sunyaev,Shamil R. Sunyaev,Bonnie Berger,Albert-László Barabási,Albert-László Barabási,Benoit Charloteaux,David E. Hill,Tong Hao,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,Yu Xia,Yu Xia,Albertha J.M. Walhout,Albertha J.M. Walhout,Susan Lindquist,Susan Lindquist,Marc Vidal +61 more
TL;DR: This work functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays, suggesting that disease-associated alleles that perturb distinct protein activities rather than grossly affecting folding and stability are relatively widespread.