Miklos Nyerges

Bio: Miklos Nyerges is an academic researcher from Budapest University of Technology and Economics. The author has contributed to research in topics: Azomethine ylide & Cycloaddition. The author has an hindex of 11, co-authored 91 publications receiving 394 citations. Previous affiliations of Miklos Nyerges include Szent István University & RMIT University.

1,7-Electrocyclizations of Azomethine Ylides : Scope and Synthetic Aspects

Abstract: The 1,3-dipolar cycloaddition of azomethine ylides is a versatile and efficient tool for the construction of five-membered nitrogen heterocycles. When the azomethine ylide is conjugated with double bonds other pericyclic pathways become available, including 1,5- or 1,7-electrocyclizations, with the latter 8π-electron process having only recently emerged as a potentially useful method for the formation of seven-membered heterocycles. Under special structural circumstances, multistep rearrangements can also be observed. In this account, a summary of our work on the exploration and development of 1,7-electrocyclizations of azomethine ylides is presented. 1 Introduction 2 Electrocyclizations 2.1 Reaction of β-Phenylcinnamaldehyde with Amino Acids: The First 1,7-Electrocyclization of Nonstabilized Azomethine Ylides 2.2 Synthesis of Azepines from Unsaturated Aldehydes and Sarcosine via 1,7-Electrocyclizations 2.3 Electrocyclizations of Stabilized Azomethine Ylides 2.4 Electrocyclizations of Azomethine Ylides onto a N=O Double Bond 3 Conclusions

New indolizine derivatives, method for preparing same and pharmaceutical compositions containing same

Abstract: Compounds of formula (I) wherein R a , Rb, Rc, Rd, R1, R2, R3, R4, R5; X, Y and Het are as defined in the description.

Construction of pyrrolo[3,2-c]quinolines: Recent advances in the synthesis of the martinelline alkaloids

Abstract: The synthesis of pyrrolo[3,2,c]quinolines is comprehesively reviewed. Synthetic approaches to martinelline alkaloids are then considered which are based upon the endeavors in this area by three independent groups.

Synthesis and reactions of reduced flavones

Abstract: The cycloadditions of a series of 4H-pyran-4-ones 3c–e with electron-rich dienes 11a,b to give reduced flavones 12 is described. The subsequent reactions of these reduced flavones with HCl, trifluoroacetic anhydride, ethyl anthranilate 19a and anthranilonitrile 19b is also described.

Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes

Abstract: Photoexcited electron-hole pairs on a semiconductor surface can engage in redox reactions with two different substrates. Similar to conventional electrosynthesis, the primary redox intermediates afford only separate oxidized and reduced products or, more rarely, combine to one addition product. Here, we report that a stable organic semiconductor material, mesoporous graphitic carbon nitride (mpg-CN), can act as a visible-light photoredox catalyst to orchestrate oxidative and reductive interfacial electron transfers to two different substrates in a two- or three-component system for direct twofold carbon-hydrogen functionalization of arenes and heteroarenes. The mpg-CN catalyst tolerates reactive radicals and strong nucleophiles, is straightforwardly recoverable by simple centrifugation of reaction mixtures, and is reusable for at least four catalytic transformations with conserved activity.

Use of Bromine and Bromo-Organic Compounds in Organic Synthesis

Abstract: Bromination is one of the most important transformations in organic synthesis and can be carried out using bromine and many other bromo compounds. Use of molecular bromine in organic synthesis is well-known. However, due to the hazardous nature of bromine, enormous growth has been witnessed in the past several decades for the development of solid bromine carriers. This review outlines the use of bromine and different bromo-organic compounds in organic synthesis. The applications of bromine, a total of 107 bromo-organic compounds, 11 other brominating agents, and a few natural bromine sources were incorporated. The scope of these reagents for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, ring-opening reactions, substitution, rearrangement, hydrolysis, catalysis, etc. has been described briefly to highlight important aspects of the bromo-organic compounds in organic synthesis.