M
Miklós Péter Kalapos
Researcher at Semmelweis University
Publications - 32
Citations - 1419
Miklós Péter Kalapos is an academic researcher from Semmelweis University. The author has contributed to research in topics: Methylglyoxal & Gluconeogenesis. The author has an hindex of 13, co-authored 29 publications receiving 1326 citations.
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Journal ArticleDOI
Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications.
TL;DR: A comprehensive overview of methylglyoxal research, extending discussion from chemistry to biological implications by reviewing some important characteristics of methyl glyoxal metabolism and toxicity in a wide variety of species, and emphasizing the action of methyl-oxoaldehyde production in the environment as a potential risk factor and to the possible role of this a-dicarbonyl in diseases as discussed by the authors.
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The tandem of free radicals and methylglyoxal.
TL;DR: It is arrived at that a tight junction exists between methylglyoxal toxicity and free radical (particularly ROS) generation, though the toxicity of 1,2-dicarbonyl evolves even under anaerobic conditions, too.
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On the mammalian acetone metabolism: from chemistry to clinical implications.
TL;DR: A trial is made to ascertain a comprehensive overview of acetone research extending discussion from chemistry to clinical implications and the possible future directions of research upon acetone are depicted by emphasizing the need for the clear-cut identification of mammalian acetoacetate decarboxylase, and the investigation of race differences and genetic background of acet one metabolism.
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Methylglyoxal and glucose metabolism: a historical perspective and future avenues for research.
TL;DR: An overview of the changing role of methylglyoxal from a historical aspect is given and it is arrived at that methyl glyoxal is tightly bound to glycolysis from an evolutionary perspective, its production therefore being inevitable.
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Methylglyoxal toxicity in mammals
TL;DR: The effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules and the theories on the role of methyl Glyoxal and glyoxalases are discussed.